{"paper_id":"d5064ab5-590f-4f2c-8f74-02b313d4ab56","body_text":"Abstract\nPurpose: Our purpose was to examine the effect of treated mild pelvic disease on the outcome of superovulation with intrauterine insemination (SO/IUI).\nMethods: Three hundred cycles of SO/IUI were retrospectively reviewed for 118 women with laparoscopically treated minimal/mild endometriosis and 67 cycles for 28 women with minimal/mild distal tubal disease/adnexal adhesions and compared with 265 cycles in 111 couples with idiopathic infertility.\nResults: The monthly fecundity rate (MFR) of 6.8% and live birth rate (LBR) of 6% in the endometriosis group were significantly lower (P = 0.002) than those in the idiopathic infertility group (MFR = 13.5%, LBR = 12.1%). The 10.9% MFR and 7.5% LBR in the minimal/mild tubal/adnexal disease were not significantly different from those in the other two groups.\nConclusions: MFR and LBR were higher after SO/IUI in idiopathic infertility compared to those for treated mild/minimal endometriosis or mild/minimal tubal/adnexal adhesions. However, SO/IUI still remains a reasonable option for both these groups prior to IVF-ET.\nSimilar content being viewed by others\nREFERENCES\nCollins JA, Burrows EA, Willan AR: The prognosis for live birth among untreated infertile couples. Fertil Steril 1995;64:22-28\nTummon I, Asher L, Martin J, Tulandi T: Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. Fertil Steril 1997;68:8-12\nFedele L, Bianchi S, Marchini M, Villa L, Brioschi D, Parazzini F: Superovulation with human menopausal gonadotrophins in the treatment of infertility associated with minimal or mild endometriosis: A controlled randomized study. Fertil Steril 1992;58:28-31\nMarcoux S, Maheux R, Sylvie Berube, Canadian Collaborative Group on Endometriosis: Laparoscopic surgery in infertile women with minimal or mild endometriosis. N Engl J Med 1997;337:217-222\nHendin B, Falcone T, Hallak J, Nelson D, Vemullapalli S, Goldberg J, Thomas A, Agarwal A: The effect of patient and semen characteristics on live birth rates following intrauterine insemination: A retrospective study. J Assist Reprod Genet 2000;17:245-252\nAmerican Fertility Society: Revised classification of endometriosis. Fertil Steril 1985;43:351-352\nAmerican Fertility Society: The American Fertility Society classification of adnexal pregnancies, to tubal ligation, adhesions, distal tubal occlusion, tubal occlusion secondary tubal Mullerian anomalies and intrauterine adhesions. Fertil Steril 1988;49:944-955\nNulsen JC, Walsh S, Dumez S, Metzer D: A Randomized and Longitudinal study of human menopausal gonadotrophin with intrauterine insemination in the treatment of infertility. Obstet Gynecol 1993;82:780-786\nDodson WC, Haney AF: Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertility. Fertil Steril 1991;55:457-465\nGuzick DS, Carson SA, Coutifaris C, Overstreet JW, Factor-Litvak P, Steinkampf MP, Joseph A, Mastroianni LJ, Buster JE, Nakajima ST, Vogel DL, Canfield RE: Efficacy of superovulation and intrauterine insemination in the treatment of infertility. N Engl J Med 1999;340:177-183\nAgarwell SK, Buyalos RP: Clomiphene citrate with intrauterine insemination: Is it effective therapy in women above the age of 35 years? Fertil Steril 1996;65:759-763\nCorsan G, Trias A, Trout S, Kemmann E: Ovulation induction combined with intrauterine insemination in women of 40 years of age and older: Is it worthwhile? Hum Reprod 1996; 11:1109-1112\nLenton EA, Weston GA, Cooke ID: Long-term follow-up of the apparently normal couple with a complaint of infertility. Fertil Steril 1977;28:913-919\nMatson PL, Yovich JL: The treatment of infertility associated with endometriosis by in vitro fertilization. Fertil Steril 1986;46:432-434\nGoverde AJ, McDonnell J, Vermeiden JPW, Schats R, Rutten FFH, Schoemaker J: Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: A randomised trial and cost-effectiveness analysis. Lancet 2000;355:13-18\nPeterson CM, Hatasaka HH, Jones KP, Poulson AM, Carrell DT, Urry RL: Ovulation induction with gonadotrophins and intrauterine insemination compared with in vitro fertilization and no therapy: A prospective, nonrandomized, cohort study and metaanalysis. Fertil Steril 1994;62:535-544\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nSingh, M., Goldberg, J., Falcone, T. et al. Superovulation and Intrauterine Insemination in Cases of Treated Mild Pelvic Disease. J Assist Reprod Genet 18, 26–29 (2001). https://doi.org/10.1023/A:1026446612485\nIssue date:\nDOI: https://doi.org/10.1023/A:1026446612485","source_license":"CC0","license_restricted":false}