Efficacy of every-other-day administration of conjugated equine estrogen and medroxyprogesterone acetate on gonadotropin-releasing hormone agonists treatment in women with endometriosis

Irahara M, M Irahara, Hirokazu Uemura, Uemura H, H Uemura, Yasui T, Toshiyuki Yasui, T Yasui, Kinoshita H, H Kinoshita, Hiromi Kinoshita, M. Yamada, Masayo Yamada, Yamada M, M Tezuka, Michiko Tezuka, Tezuka M, Machiko Kiyokawa, M Kiyokawa, Kiyokawa M, M Kamada, Masaharu Kamada, Kamada M, T Aono, Toshihiro Aono, Aono T
Gynecologic and obstetric investigation · 2001 · vol. 52(4) , pp. 217–222 · doi:10.1159/000052978 · PMID:11729332 · W2043863194
RCT OA: closed CC0 ⤵ 11 in-corpus citations
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This study found that adding conjugated equine estrogen and medroxyprogesterone acetate every other day to GnRH agonist treatment reduced symptom scores and prevented bone loss in women with endometriosis.

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Abstract

We performed a randomized controlled study to determine the efficacy of add-backed therapy by every-other-day administration of 0.625 mg conjugated equine estrogen (CEE) and 2.5 mg medroxyprogesterone acetate (MPA) on GnRH agonists (GnRH-a) treatment in Japanese women with symptomatic endometriosis. At the end of treatment, serum estrone and estradiol levels in the add-back group (n = 11) were significantly higher than those in the control group (n = 10). The assessment of Beecham classification by bimanual examination, serum CA-125 levels, and the frequency of genital bleeding revealed no significant differences between the two groups. The add-back group showed reduced Kupperman indices relative to those of the control group, and could prevent the loss of bone density. These findings led to a conclusion that GnRH-a therapy added back by every-other-day administration of 0.625 mg CEE and 2.5 mg MPA was a safe and effective treatment for Japanese women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogens, Conjugated (USP) Gonadotropin-Releasing Hormone Medroxyprogesterone Acetate Adult Adult Animals Animals Bone Density Bone Density Bone Remodeling Bone Remodeling CA-125 Antigen CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Estradiol Estradiol Estradiol

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (11)

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