Endometrial effects of long-term low-dose administration of RU486

A A Murphy, Ana A. Murphy, Murphy AA, Kettel LM, L. Michael Kettel, L M Kettel, Arlene J. Morales, A J Morales, Morales AJ, V Roberts, Roberts V, Veronica J. Roberts, Parmley T, Tim H. Parmley, T Parmley, S S Yen, Samuel S.C. Yen, Yen SS
Fertility and sterility · 1995 · vol. 63(4) , pp. 761–766 · doi:10.1016/s0015-0282(16)57478-0 · PMID:7890059 · W2290286119
article OA: closed CC0 ⤵ 22 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This paper investigated the effects of long-term, low-dose RU486 administration on the endometrium in a rodent model.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo examine endometrial response to long-term low-does RU486 administration.DesignRetrospective controlled study of women with endometriosis treated for 6 months with 50 mg RU486 daily for 6 months. Controls consisted of women in the follicular phase of a spontaneous cycle undergoing endometrial biopsy.SettingPatients from the clinical practice of the authors at the University of California, San Diego Medical Center.Patients and interventionsNine patients treated with long-term low-dose RU486 and nine normal cycling controls undergoing hysterectomy or endometrial biopsy for benign disease.Main outcome measuresChanges in endometrial morphology and immunohistochemical analysis for estrogen receptor (ER) and progesterone receptor (PR) protein.ResultsAll patients treated with RU486 exhibited abnormal endometrial morphology. The endometrial glands were irregular in size and shape. The stroma was varied but consisted predominantly of dense cellular stroma with frequent mitotic figures. The glands were lined by a combination of epithelial types some of which were secretory. No cytologic atypia was seen. Levels of ER immunoreactivity, as determined by image analysis, were greater in the stroma with no difference in PR immunoreactivity compared with controls. No difference in ER and PR immunoreactivity were seen in the glands compared with normal controls.ConclusionThe generalized cystic changes demonstrated are consistent with a chronic unopposed estrogen effect and are concordant with hormonal data showing early to midfollicular phase levels of estrogens. They also are consistent with our findings of increased ER immunoreactivity in the stroma. Evidence of minimal P agonist effect was noted.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometrium Mifepristone Adolescent Adult Dose-Response Relationship, Drug Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Image Processing, Computer-Assisted Immunohistochemistry Menstrual Cycle Middle Aged Mifepristone Mifepristone Receptors, Estrogen Receptors, Estrogen

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (22)

Source provenance

europepmc
last seen: 2026-08-01T06:07:04.264727+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:13.665691+00:00
License: CC0 · commercial use OK