Endometrial effects of long-term low-dose administration of RU486

A A Murphy, Ana A. Murphy, Murphy AA, Kettel LM, L. Michael Kettel, L M Kettel, Arlene J. Morales, A J Morales, Morales AJ, V Roberts, Roberts V, Veronica J. Roberts, Parmley T, Tim H. Parmley, T Parmley, S S Yen, Samuel S.C. Yen, Yen SS
Fertility and sterility · 1995 · vol. 63(4) , pp. 761–766 · doi:10.1016/s0015-0282(16)57478-0 · PMID:7890059 · W2290286119
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This paper investigated the effects of long-term, low-dose RU486 administration on the endometrium in a rodent model.

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Abstract

OBJECTIVE: To examine endometrial response to long-term low-does RU486 administration. DESIGN: Retrospective controlled study of women with endometriosis treated for 6 months with 50 mg RU486 daily for 6 months. Controls consisted of women in the follicular phase of a spontaneous cycle undergoing endometrial biopsy. SETTING: Patients from the clinical practice of the authors at the University of California, San Diego Medical Center. PATIENTS AND INTERVENTIONS: Nine patients treated with long-term low-dose RU486 and nine normal cycling controls undergoing hysterectomy or endometrial biopsy for benign disease. MAIN OUTCOME MEASURES: Changes in endometrial morphology and immunohistochemical analysis for estrogen receptor (ER) and progesterone receptor (PR) protein. RESULTS: All patients treated with RU486 exhibited abnormal endometrial morphology. The endometrial glands were irregular in size and shape. The stroma was varied but consisted predominantly of dense cellular stroma with frequent mitotic figures. The glands were lined by a combination of epithelial types some of which were secretory. No cytologic atypia was seen. Levels of ER immunoreactivity, as determined by image analysis, were greater in the stroma with no difference in PR immunoreactivity compared with controls. No difference in ER and PR immunoreactivity were seen in the glands compared with normal controls. CONCLUSION: The generalized cystic changes demonstrated are consistent with a chronic unopposed estrogen effect and are concordant with hormonal data showing early to midfollicular phase levels of estrogens. They also are consistent with our findings of increased ER immunoreactivity in the stroma. Evidence of minimal P agonist effect was noted.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Mifepristone Adolescent Adolescent Adult Adult Dose-Response Relationship, Drug Dose-Response Relationship, Drug Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Humans Humans Image Processing, Computer-Assisted

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (21)

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