A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis
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This randomized trial compared two doses of gestrinone for endometriosis treatment, assessing their efficacy and safety profiles.
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Abstract
The purpose of this randomized double blind prospective trial was to study the efficacy and safety of two doses of oral gestrinone in the treatment of endometriosis. Six patients received gestrinone 1.25 mg twice weekly (group I) and six patients received gestrinone 2.5 mg twice weekly (group II). Patients underwent pretreatment and post-treatment laparoscopies and their endometriosis scores were recorded. The mean total endometriosis scores declined significantly from 20.0 +/- 5.2 (mean +/- standard error of the mean) pretreatment to 9.5 +/- 3.9 post-treatment in group I and from 19.1 +/- 4.8 pretreatment to 7.1 +/- 2.1 post-treatment in group II. A total of 67% of patients reported side effects. This study suggests that oral gestrinone 1.25 mg or 2.5 mg twice weekly is efficacious and safe in the treatment of endometriosis.
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Cited by (33)
- Progestagens for pain symptoms associated with endometriosis 2025
- Evaluation of safety and effectiveness of gestrinone in the treatment of endometriosis: a systematic review and meta-analysis 2022
- Endometriosis 2021
- Progesterone receptor modulators for endometriosis 2017
- Progestagens and anti-progestagens for pain associated with endometriosis 2012
- Endometriosis 2012
- Treatment of pelvic pain associated with endometriosis 2008
- Current Approaches to Optimizing the Treatment of Endometriosis in Adolescents 2008
- Medical Management of Endometriosis 2008
- Endometriosis 2008
- Endometriosis 2007
- Ovulation suppression for endometriosis for women with subfertility 2007
- The role of progestins in treating the pain of endometriosis 2006
- Treatment of pelvic pain associated with endometriosis 2006
- Modern Medical Therapy of Endometriosis 2004
- Endometriosis 2003
- Medical Management of Endometriosis: Novel Targets and Approaches towards the Development of Future Treatment Regimes 2003
- Ovulation suppression for endometriosis 2003
- Medical Therapy for Endometriosis 2003
- Progestagens and anti-progestagens for pain associated with endometriosis 2000
- Medical Treatment of Endometriosis-Associated Pain 1999
- Today's treatments: medical, surgical and in partnership 1999
- The evidence for the management of endometriosis 1998
- Endometriosis and Pelvic Pain 1998
- Voice changes in women treated for endometriosis and related conditions: The need for comprehensive vocal assessment 1998
- MODERN MEDICAL MANAGEMENT OF ENDOMETRIOSIS 1997
- Clinical, endocrine, and metabolic effects of two doses of gestrinone in treatment of pelvic endometriosis 1997
- Gestrinone versus a gonadotropin-releasing hormone agonist for the treatment of pelvic pain associated with endometriosis: a multicenter, randomized, double-blind study 1996
- 9 Endometriosis: Medical therapy 1993
- Medical management of endometriosis 1993
- Changing concepts of medical treatment of endometriosis 1993
- The use of danazol as a treatment of endometriosis 1991
- Gestogens and anti-gestogens as treatment of endometriosis 1991
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