Gonadotrophin releasing hormone agonist (buserelin) in the treatment of endometriosis: changes in the extent of the disease and in CA 125 serum levels after 6‐month therapy

R Marana, Riccardo Marana, L Muzii, L. MUZH, P Muscatello, Antonio Lanzone, A Lanzone, A Caruso, Alessandro Caruso, S Dell'Acqua, S Mancuso, Stefano Mancuso
British journal of obstetrics and gynaecology · 1990 · vol. 97(11) , pp. 1016–1019 · doi:10.1111/j.1471-0528.1990.tb02474.x · PMID:2147564 · W2057986532
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Six-month buserelin treatment of endometriosis reduced disease extent and CA 125 levels, but CA 125 did not correlate with disease scores post-treatment, questioning its utility in monitoring therapy.

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Abstract

Twenty-two women with endometriosis were treated with the luteinizing hormone-releasing hormone (LHRH) agonist buserelin for 6 months. At second-look laparoscopy the mean score of endometriosis had decreased from 23.1 (SD 17.0) to 17.2 (SD 20.2) (P less than 0.05). CA 125 serum levels decreased from 38.4 (SD 32.2) U/ml at diagnosis to 15.5 (SD 7.0) at second look (P less than 0.005). CA 125 levels correlated at diagnosis with total score of endometriosis (P less than 0.05) and with active score of endometriosis (P less than 0.05), but not with the adhesion score. CA 125 levels were not correlated with endometriosis scores at second look laparoscopy, thus suggesting that mechanisms other than the change in the extent of the disease may be involved in the CA 125 decrease during therapy. CA 125 levels may therefore not be a reliable indicator for monitoring the efficacy of LHRH agonist treatment of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Buserelin Endometriosis Uterine Neoplasms Adult Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Buserelin Endometriosis Endometriosis Endometriosis Female Humans Laparoscopy Prospective Studies Time Factors Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

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References (18)

Cited by (7)

SciLite annotations

chemicals 2
buserelin buserelin

Source provenance

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