Treatment of infertility due to endometriosis with low-dosage danazol

Constantine Samaras, R. Don Gambrell, R. B. Greenblatt
In: Diagnosis and Management of Tubo-Uterine Factors in Infertility · 1984 · pp. 117–121 · doi:10.1007/978-94-011-7621-7_23 · W943657652
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Low-dosage danazol (100–200 mg daily) was nearly as effective as high-dosage danazol in eliminating endometriosis while reducing side effects.

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This chapter examines the efficacy of low-dosage danazol, specifically 100–200 mg daily, for treating infertility associated with endometriosis. It notes that while higher doses of 800 mg are highly effective, they often cause significant side effects, whereas lower dosages provide nearly equivalent elimination of endometriotic lesions with reduced adverse reactions. The text references prior clinical studies to support the conclusion that reducing the dosage maintains therapeutic effectiveness while improving patient tolerability. This paper is centrally about endometriosis — specifically the medical management of infertility resulting from the condition using a reduced dose of danazol.

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Abstract

Danazol in dosages of 800 mg daily has been shown to be highly effective in the treatment of endometriosis; however, it may produce significant side-effects1,2. Lowering the dosage decreases the number and severity of untoward reactions, and dosages of 100–200 mg daily have been found to be nearly as effective in eliminating endometriosis as dosages of 800 mg3. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Greenblatt, R. B., Dmowski, W. P. and Mahesh, V. B. (1971). Clinical studies with an antigonadotropin - danazol. Fertil. Steril., 22, 102 Ansbacher, R. (1975). Treatment of endometriosis with danazol. Am. J. Obstet. Gynecol., 121, 283 Moore, E. E., Harger, J. H., Rick, J. A. et al. (1981). Management of pelvic endometriosis with low-dose danazol. Fertil. Steril., 36, 15 Editor information Editors and Affiliations Rights and permissions Copyright information © 1984 MTP Press Limited About this chapter Cite this chapter Samaras, C., Gambrell, R.D., Greenblatt, R.B. (1984). Treatment of infertility due to endometriosis with low-dosage danazol. In: Harrison, R.F., Bonnar, J., Thompson, W. (eds) Diagnosis and Management of Tubo-Uterine Factors in Infertility. Studies in Fertility and Sterility, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7621-7_23 Download citation DOI: https://doi.org/10.1007/978-94-011-7621-7_23 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-011-7623-1 Online ISBN: 978-94-011-7621-7 eBook Packages: Springer Book Archive

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endometriosisinfertility

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