Further studies on danazol interference in testosterone radioimmunoassays.

A M Sharp, A. Sharp, Ian S. Fraser, I S Fraser, Ian D. Caterson, I D Caterson
Clinical chemistry · 1983 · vol. 29(1) , pp. 141–3 · PMID:6848250 · W1845624885
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study demonstrates danazol interferes with testosterone radioimmunoassays, leading to falsely elevated values, and presents a chromatographic method to resolve testosterone from danazol and its metabolites.

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Abstract

Investigating the interference of danazol in testosterone radioimmunoassays, we measured serum testosterone concentrations in the serum of women receiving danazol, with three testosterone radioimmunoassay kits. All of these showed positive interference by danazol or its metabolites (or both). Values for testosterone obtained with two of the methods (Diagnostic Products Corp. and Farmos Diagnostica) depended on the volume of serum extracted per assay tube. A detailed column-chromatographic method is presented in which testosterone is resolved from danazol and its metabolites.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Pregnadienes Testosterone Chromatography Danazol Danazol Endometriosis Endometriosis False Positive Reactions Female Humans Pregnadienes Radioimmunoassay Reagent Kits, Diagnostic Testosterone Testosterone

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