Evaluation of serum anti-Mullerian hormone levels to assess the ovarian reserve in women with severe endometriosis

Arianna Pacchiarotti, Pacchiarotti A, Paola Frati, Giusi Natalia Milazzo, G. Milazzo, Milazzo GN, Catalano A, A Catalano, Angelica Catalano, Vincenzo Gentile, Moscarini M, Massimo Moscarini
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 172 , pp. 62–64 · doi:10.1016/j.ejogrb.2013.10.003 · PMID:24210790 · W2054036150
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This study investigated serum anti-Mullerian hormone levels as a measure of ovarian reserve in women diagnosed with severe endometriosis.

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Abstract

ObjectiveThe aim of this study was to measure anti-Mullerian hormone (AMH) serum levels in women with severe endometriosis, in order to demonstrate the effect of the disease on ovarian reserve.Study designProspective case-control study. One hundred and ninety-five patients were enrolled: 130 fertile patients (group A) and 65 patients with stage III and IV endometriosis, diagnosed by laparoscopy and histological examination (group B). AMH serum levels were measured in both groups and were compared using Student's t-test.ResultsThe two groups were homogenous for main demographic data. Group B had statistically significantly lower mean AMH serum levels (0.97±0.59ng/ml) than group A (1.72±0.63ng/ml) (p=0.001).ConclusionsThis study is a demonstration of the damage of endometriosis on ovarian reserve, leading to a form of incipient ovarian failure, which is considered as an early sign of advanced ovarian depletion in young women. These findings suggest that AMH could be used in the follow-up of patients with endometriosis, in order to assess promptly the decrease of ovarian reserve.

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Condition tags

endometriosis

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Oocytes Ovary Primary Ovarian Insufficiency Adult Anti-Mullerian Hormone Case-Control Studies Endometriosis Endometriosis Female Humans Laparoscopy Primary Ovarian Insufficiency Severity of Illness Index

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