Accuracy of anogenital distance and anti‐Müllerian hormone in the diagnosis of endometriosis without surgery

María L Sánchez-Ferrer, María Luisa Sánchez-Ferrer, Raquel Jiménez-Velázquez, Raquel Jiménez‐Velázquez, Jaime Mendiola, María T Prieto-Sánchez, María T. Prieto‐Sánchez, Laura Cánovas-López, Laura Cánovas‐López, Ana Carmona-Barnosi, Ana Carmona‐Barnosi, Shiana Corbalán‐Biyang, Shiana Corbalán-Biyang, Ana I Hernández-Peñalver, Ana I. Hernández‐Peñalver, Evdochia Adoamnei, A. Nieto, Aníbal Nieto, Alberto M. Torres‐Cantero, Alberto M Torres-Cantero
International Journal of Gynecology & Obstetrics · 2018 · vol. 144(1) , pp. 90–96 · doi:10.1002/ijgo.12691 · PMID:30298915 · W2896741212
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that shorter anogenital distance (AGD AF) and lower anti-Müllerian hormone (AMH) levels are significantly associated with endometriosis and can aid in its diagnosis without surgery.

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Abstract

Abstract Objective To assess the predictive ability of a combination of anogenital distance ( AGD ) and anti‐Müllerian hormone ( AMH ) to diagnosis the presence of endometriosis without surgery. Methods The present study included women diagnosed with endometriosis and a control group who attended the “Virgen de la Arrixaca” University Hospital, Murcia, Spain, between September 1, 2014, and May 31, 2015. Serum concentrations of AMH were measured, and two AGD measurements were obtained: from the anterior clitoral surface to the upper verge of the anus ( AGD AC ), and from the posterior fourchette to the upper verge of the anus ( AGD AF ). Data were assessed by receiver operator characteristic ( ROC ) curves. Results Women in the endometriosis group (n=57) had significantly shorter AGD AF (22.8 ± 4.6 vs 27.2 ± 5.7 mm; P <0.001) and lower AMH (2.2 ± 2.5 vs 3.3 ± 1.9 ng/ mL ; P <0.003) compared with the control group (n=93). Women with serum AMH below the clinical cut‐off (1 ng/ mL ) were 17.40‐times more likely to have endometriosis (95% confidence interval [ CI ] 5.64–53.82). The area under the ROC curve of combined AMH and AGD AF was 0.77 (95% CI 0.70–0.85). Conclusion The model for predicting endometriosis on the basis of AMH and AGD could be useful for clinicians and epidemiologists to improve diagnosis and prognosis of this condition.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Anal Canal Anti-Mullerian Hormone Endometriosis Genitalia, Female Adult Anal Canal Anti-Mullerian Hormone Biomarkers Biomarkers Case-Control Studies Endometriosis Endometriosis Female Genitalia, Female Humans Predictive Value of Tests ROC Curve Young Adult

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