Accuracy of anogenital distance and anti-Müllerian hormone in the diagnosis of endometriosis without surgery

María Luisa Sánchez-Ferrer, María L Sánchez-Ferrer, Jiménez-Velázquez R, Raquel Jiménez-Velázquez, Raquel Jiménez‐Velázquez, Jaime Mendiola, María T Prieto-Sánchez, María T. Prieto‐Sánchez, Laura Cánovas‐López, Cánovas-López L, Laura Cánovas-López, Ana Carmona-Barnosi, Ana Carmona‐Barnosi, Carmona-Barnosi A, Shiana Corbalán‐Biyang, Corbalán-Biyang S, Shiana Corbalán-Biyang, Ana I. Hernández‐Peñalver, Hernández-Peñalver AI, Ana I Hernández-Peñalver, Evdochia Adoamnei, Nieto A, Aníbal Nieto, A. Nieto, Alberto M. Torres‐Cantero, Alberto M Torres-Cantero
International Journal of Gynecology & Obstetrics · 2018 · vol. 144(1) , pp. 90–96 · doi:10.1002/ijgo.12691 · PMID:30298915 · W2896741212
Diagnostic accuracy OA: closed CC0 ⤵ 15 in-corpus citations
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This study found that shorter anogenital distance (AGD AF) and lower anti-Müllerian hormone (AMH) levels are significantly associated with endometriosis and can aid in its diagnosis without surgery.

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Abstract

OBJECTIVE: To assess the predictive ability of a combination of anogenital distance (AGD) and anti-Müllerian hormone (AMH) to diagnosis the presence of endometriosis without surgery. METHODS: The present study included women diagnosed with endometriosis and a control group who attended the "Virgen de la Arrixaca" University Hospital, Murcia, Spain, between September 1, 2014, and May 31, 2015. Serum concentrations of AMH were measured, and two AGD measurements were obtained: from the anterior clitoral surface to the upper verge of the anus (AGDAC ), and from the posterior fourchette to the upper verge of the anus (AGDAF ). Data were assessed by receiver operator characteristic (ROC) curves. RESULTS: Women in the endometriosis group (n=57) had significantly shorter AGDAF (22.8 ± 4.6 vs 27.2 ± 5.7 mm; P<0.001) and lower AMH (2.2 ± 2.5 vs 3.3 ± 1.9 ng/mL; P<0.003) compared with the control group (n=93). Women with serum AMH below the clinical cut-off (1 ng/mL) were 17.40-times more likely to have endometriosis (95% confidence interval [CI] 5.64-53.82). The area under the ROC curve of combined AMH and AGDAF was 0.77 (95% CI 0.70-0.85). CONCLUSION: The model for predicting endometriosis on the basis of AMH and AGD could be useful for clinicians and epidemiologists to improve diagnosis and prognosis of this condition.

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Condition tags

endometriosis

MeSH descriptors

Anal Canal Anti-Mullerian Hormone Endometriosis Genitalia, Female Adult Adult Anal Canal Anal Canal Anti-Mullerian Hormone Anti-Mullerian Hormone Biomarkers Biomarkers Biomarkers Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

Cited by (14)

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