A Real-world Study of Changes in Preoperative and Postoperative CA125, A and M H in Patients with Endometriosis

To investigate the changes of ovarian reserve function in real-world of patients diagnosed endometriosis with different stages, preoperative and postoperative, respectively. Ananlysis the relationship between anti-mullerian hormone (AMH) and CA125. A total of 50 patients operatived because of uterine myoma and 185 patients diagnosed endometriosis from 2014 to June 2020 were inrolled. Of the endometriosis patients, 70 patients with stage Ⅰ-Ⅱ and 115 patients with stage Ⅲ-Ⅳ. The groups were redivided into group A(≤35years) and group B (>36) based on age. The serum CA125 and AMH was tested preoperative, retested the AMH1 and 6 months postoperaive. Then analyzed these data by statistical methods. ① There is no statistical significance in the same age groups versus preoperative blood AMH in patients with Ⅰ-Ⅱ stage endometriosis groups and in the myoma patients (P> 0.05), compared to the Ⅲ-Ⅳ stage of endometriosis, the AMH were high in the myoma groups and Ⅰ-Ⅱ stage endometriosis groups (P 0.05)in the Ⅰ-Ⅱ stage endometriosis a groups, the AMH decreased 1 month after operation, whereas there was no significant decrease 6 months after operation compared to preoperative, and the difference had not statistically significance (P> 0.05). In the Ⅲ-Ⅳ stage endometriosis groups, the AMH decreased after operation in 1 and 6 months, and the difference had statistically significance (P <0.05). ③ The CA125 was significantly higher in advanced endometriosis stages compared to the Ⅰ-Ⅱ stage groups and uterine myoma groups, and was negatively correlated with preoperative AMH.