Association Between Dietary Vitamin B1 and the Risk of Endometriosis: A Cross-Sectional Study Based on NHANES 2003–2006

Jing Zhang, Huiwen Guo, Zhigang Zhou
In: bioRxiv · 2025 · doi:10.1101/2025.02.21.639433 · W4408007512
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This cross-sectional study found that higher dietary vitamin B1 intake was significantly associated with a reduced risk of endometriosis in NHANES 2003–2006 data, with a protective effect observed above 1.84 mg/day.

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Abstract

Abstract Endometriosis is a chronic gynecological condition influenced by inflammation and oxidative stress. Dietary vitamin B1 plays a role in reducing oxidative stress, which may influence endometriosis risk. However, limited research explores this association. Objective To investigate the association between dietary vitamin B1 intake and the risk of endometriosis, using NHANES 2003–2006 data. Vitamins B2 and B6 are included as reference comparisons. Methods Data from 2,462 participants in NHANES 2003–2006 were analyzed. Logistic regression models were used to examine the association between vitamin B1 intake and endometriosis risk, with adjustments for covariates. Subgroup analyses and restricted cubic spline (RCS) regressions were applied to assess non-linear relationships. Vitamins B2 and B6 served as reference nutrients for comparison. Results Vitamin B1: Higher intake of dietary vitamin B1 was significantly associated with reduced risk of endometriosis (OR = 0.76, 95% CI: 0.58– 0.99, P = 0.044 in Model 4). Vitamin B2 and B6: No significant associations were observed (P > 0.05). RCS regression demonstrated a non-linear relationship for vitamin B1, with a protective effect observed at intake levels > 1.84 mg/day. Conclusion Higher dietary vitamin B1 intake is associated with a reduced risk of endometriosis. While B2 and B6 showed no significant associations, their trends provide additional insight for future research.

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Condition tags

endometriosis

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References (30)

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