Application Progress of Noninvasive Biomarkers in the Diagnosis of Endometriosis

文娜 王
In: Advances in Clinical Medicine · 2023 · vol. 13(02) , pp. 2759–2764 · doi:10.12677/acm.2023.132389 · W4321787759
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This review summarizes recent research progress on noninvasive diagnostic methods and biomarkers for endometriosis, a common disease with unclear pathogenesis and high recurrence rates.

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This review article examines the current landscape of noninvasive biomarkers for diagnosing endometriosis, a condition characterized by high recurrence rates and diagnostic challenges that currently rely on laparoscopic biopsy as the gold standard. The authors synthesize recent studies evaluating various serum and tissue markers, including inflammatory cytokines, oxidative stress indicators, and microRNAs, while noting the significant limitation that no single biomarker currently offers both high sensitivity and specificity for clinical use. The paper highlights that combining different noninvasive methods or exploring novel marker combinations represents a promising direction for future research to reduce diagnostic delays. This paper is centrally about endometriosis — specifically focusing on the development and evaluation of noninvasive diagnostic biomarkers.

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无创生物标志物在子宫内膜异位症诊断中的应用进展 Application Progress of Noninvasive Biomarkers in the Diagnosis of Endometriosis Application Progress of Noninvasive Biomarkers in the Diagnosis of Endometriosis DOI: 10.12677/ACM.2023.132389, PDF, 被引量 作者: 王文娜, 陈志芳*：新疆医科大学第一附属医院，新疆 乌鲁木齐 关键词: 子宫内膜异位症；生物标志物；Endometriosis； Biomarker 作者: 王文娜, 陈志芳*：新疆医科大学第一附属医院，新疆 乌鲁木齐 关键词: 子宫内膜异位症；生物标志物；Endometriosis； Biomarker 摘要: 子宫内膜异位症作为一种育龄期妇女常见疾病，近年来呈明显上升趋势。其发病机制在很大程度上仍不清楚，且诊断治疗难度大，术后复发率高，严重影响患者的生活质量及身心健康。腹腔镜下直视、活检病理确诊仍是目前内异症诊断的金标准。目前临床上越来越多关于非侵入性指标的研究有望减少内异症的诊断延迟，但至今尚未发现敏感性和特异性均较高的理想指标。非侵入性方法的新组合以及对新的生物标志物的进一步探索可能成为未来的研究热点，本文对近年来有关内异症非侵入性诊断方法及生物标记物的研究进展予以综述。 Abstract: Endometriosis, as a common disease in women of childbearing age, has shown a significant upward trend in recent years. Its pathogenesis is still largely unclear, and the diagnosis and treatment are difficult, and the recurrence rate is high, which seriously affects the quality of life and physical and mental health of patients. Laparoscopic direct vision and biopsy are still the gold standard for the diagnosis of endometriosis. At present, more and more clinical studies on non- invasive indicators are expected to reduce the diagnostic delay of endometriosis, but no ideal indicators with high sen-sitivity and specificity have been found. New combinations of noninvasive methods and further ex-ploration of new biomarkers may become research hotspots in the future. This article reviews the research progress of noninvasive diagnostic methods and biomarkers for endometriosis in recent years. 文章引用：王文娜, 陈志芳. 无创生物标志物在子宫内膜异位症诊断中的应用进展[J]. 临床医学进展, 2023, 13(2): 2759-2764. https://doi.org/10.12677/ACM.2023.132389 | [1] | Taylor, H.S., Kotlyar, A.M. and Flores, V.A. (2021) Endometriosis Is a Chronic Systemic Disease: Clinical Challenges and Novel Innovations. The Lancet, 397, 839-852. [Google Scholar] [CrossRef] | | [2] | 郎景和. 对子宫内膜异位症认识的历史、现状与发展[J]. 中国实用妇科与产科杂志, 2020, 36(3): 193-196. | | [3] | Kiesel, L. and Sourouni, M. 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