Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

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Amine oxidase 3 was identified as a novel pro-inflammatory marker of oxidative stress within peritoneal endometriosis lesions.

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This author correction to a Scientific Reports article addresses an error in Figure 5A by updating the chemical structure of the AOC3 inhibitor PXS-4681A. The corrected figure legend specifies that the compound was synthesized according to literature procedures and describes related data shown in Figure 5, including unbound plasma levels, target engagement results, changes in plasma H2O2, plasma exposure at day 2, and dynamic weight bearing measures indicating reduced pain behavior in an endometriosis inoculation mouse model. The authors’ stated limitation is that only the figure structure/legend content is corrected, with no additional new experimental results provided. This paper is centrally about endometriosis — it corrects the presentation of data on an AOC3 inhibitor assessed in an endometriosis inoculation mouse model.

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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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1Scientific RepoRtS | (2020) 10:5665 | https://doi.org/10.1038/s41598-020-62492-z www.nature.com/scientificreports Author correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions Marie-Laëtitia thézénas, Bianca De Leo, Alexis Laux-Biehlmann, cemsel Bafligil , Bernd elger, thomas t apmeier , Karl Morten, nilufer Rahmioglu, Stephanie G. Dakin, philip ch arles , fernando estrada Martinez, Graham Steers, oliver M. fi scher, Joerg Mueller, Holger Hess-Stumpp, Andreas Steinmeyer, Sanjiv Manek, Krina t. Zondervan , Stephen Kennedy, christian M. Becker , catherine Shang, thomas M. Zollner, Benedikt M. Kessler & Udo oppermann Correction to: Scientific Reports https://doi.org/10.1038/s41598-020-58362-3, published online 30 January 2020 In Figure 5A, the chemical structure is incorrect. As a result, the Figure legend, “ AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model. (A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F ) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment. ” should read: “ AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model. (A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. The compound was synthe- sized according to literature procedures 37 (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment. ” The correct Figure 5 and its accompanying legend appear below as Figure 1. Published: xx xx xxxx open 2Scientific RepoRtS | (2020) 10:5665 | https://doi.org/10.1038/s41598-020-62492-z www.nature.com/scientificreportswww.nature.com/scientificreports/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre- ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per- mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020 Figure 1. AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model. (A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. The compound was synthesized according to literature procedures37 (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment.

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endometriosis

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