Allelic loss studies do not provide evidence for the "endometriosis-as-tumor" theory

Amanda Prowse, Prowse AH, Amanda H Prowse, Giannoulis Fakis, Fakis G, Manek S, Sanjiv Manek, Michael Churchman, Sarah E. Edwards, Edwards S, Sarah Edwards, Andrew Rowan, Rowan A, Philippe R. Koninckx, Koninckx P, Philippe Koninckx, Stephen Kennedy, Kennedy S, Ian P M Tomlinson, Tomlinson IP, Ian Tomlinson
Fertility and sterility · 2005 · vol. 83(4) , pp. 1134–1143 · doi:10.1016/j.fertnstert.2004.07.982 · PMID:15831286 · W2090811757
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This study investigated allelic loss patterns in endometriosis tissues to determine if they exhibit tumor-like genetic alterations.

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Abstract

OBJECTIVE: To identify consistent genetic changes in endometriosis samples to determine whether endometriosis lesions are true neoplasms. DESIGN: We analyzed ovarian endometriosis lesions for loss of heterozygosity (LOH) at 12 loci of potential importance (D9S1870, D9S265, D9S270, D9S161, D11S29, D1S199, D8S261, APOA2, PTCH, TP53, D10S541, and D10S1765), including some at which genetic changes were previously reported in endometriosis. SETTING: Molecular biology laboratory in a university hospital department. PATIENT(S): Seventeen women with ovarian endometriosis. INTERVENTION(S): Laser capture microdissection to separate the endometriotic epithelium, the adjacent endometriotic stroma, and surrounding normal ovarian stromal tissue, followed by DNA extraction and polymerase chain reaction amplification of polymorphic microsatellite markers. MAIN OUTCOME MEASURE(S): Fluorescence-based quantitation for the LOH analysis. RESULT(S): We identified LOH in only one lesion at one locus (D8S261). CONCLUSION(S): Our data do not support the hypothesis that ovarian endometriosis is a true neoplasm.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Loss of Heterozygosity Loss of Heterozygosity Ovarian Neoplasms Ovarian Neoplasms Adult Adult Alleles Alleles Endometriosis Endometriosis Epithelial Cells Epithelial Cells Epithelial Cells Female Female Humans Humans Microsatellite Repeats

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (44)

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