Histologies That Cross Organ Types

Amanda Jackson, Preetha Ramalingam
In: Textbook of Uncommon Cancer · 2017 · pp. 508–517 · doi:10.1002/9781119196235.ch34 · W2592124732
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This chapter reviews gynecological neoplasms like endometriosis-associated, neuroendocrine, germ cell, and extrauterine stromal tumors that share histologies across organ types, presenting unique clinical features and management considerations.

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Abstract

Gynecological cancers are a heterogeneous group of neoplasms. While most of these tumors have distinct histological, immunophenotypic, and molecular findings, significant overlap can occur. This chapter focuses on tumors that have histologies that cross organ types yet have unique clinical features, and, in some cases, significantly different management based on their site of occurrence. These distinctions are usually the focus of case reports, but impact clinical management enough to warrant a separate discussion. Such neoplasms include: endometriosis-associated tumors, such as endometrioid adenocarcinoma and clear cell carcinoma; neuroendocrine carcinomas; germ cell tumors, particularly yolk sac tumors that can present in the uterus or vagina; and extrauterine endometrioid stromal sarcomas.

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endometriosis

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