Low-Grade Endometrial Stromal Sarcoma Arising From Sciatic Nerve Endometriosis

Magali Lacroix-Triki, Magali Lacroix‐Triki, Lacroix-Triki M, Beyris L, Laurent Beyris, P. Martel, Martel P, Pierre Martel, Bernard Marques, Bernard Marquès, Marques B
Obstetrics and gynecology · 2004 · vol. 104(5) , pp. 1147–1149 · doi:10.1097/01.aog.0000128114.97877.33 · PMID:15516431 · W2318407235
article OA: closed CC0 ⤵ 22 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This case report details a low-grade endometrial stromal sarcoma that arose from sciatic nerve endometriosis in a 50-year-old woman, highlighting the potential for malignant transformation in aggressive endometriosis.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-17 · read from full text ⓘ

This case report describes a 50-year-old woman with a long history of endometriosis who presented with a left buttock mass and motor deficit due to a tumor involving the sciatic nerve. Surgical intervention including hysterectomy and excision revealed a low-grade endometrial stromal sarcoma arising from extrauterine endometriotic tissue, which subsequently progressed despite chemotherapy and radiation. The authors highlight that aggressive endometriosis can mask rare malignant neoplasms, emphasizing the diagnostic challenges associated with such presentations. This paper is centrally about endometriosis — specifically, the rare malignant transformation of sciatic nerve endometriosis into a low-grade endometrial stromal sarcoma.

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Abstract

In Brief BACKGROUND: Endometrial stromal sarcoma arising from extrauterine endometriosis is a rare and not easily diagnosed tumor. We present a case arising from sciatic nerve endometriosis in a 50-year-old woman. CASE: The patient had a long history of endometriosis and presented with a left buttock mass and motor deficit. Magnetic resonance imaging showed a large tumor of the sciatic nerve with pelvic extension. She underwent total hysterectomy, bilateral salpingo-oophorectomy, and excision of pelvic endometriotic pockets, allowing the diagnosis of low-grade endometrial stromal sarcoma arising from endometriosis. She received systemic chemotherapy, gonadotropin-releasing hormone agonist therapy, and palliative radiation therapy, but her disease progressed. CONCLUSION: Aggressive endometriosis raises important diagnostic and therapeutic difficulties and may correspond to misdiagnosed rare malignant neoplasms, which should be treated. This report of aggressive sciatic nerve endometriosis highlights the possibility of malignant transformation in cases of large, hormone-treatment-resistant and recurrent endometriosis.
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Background

Endometrial stromal sarcoma arising from extrauterine endometriosis is a rare and not easily diagnosed tumor. We present a case arising from sciatic nerve endometriosis in a 50-year-old woman. CASE: The patient had a long history of endometriosis and presented with a left buttock mass and motor deficit. Magnetic resonance imaging showed a large tumor of the sciatic nerve with pelvic extension. She underwent total hysterectomy, bilateral salpingo-oophorectomy, and excision of pelvic endometriotic pockets, allowing the diagnosis of low-grade endometrial stromal sarcoma arising from endometriosis. She received systemic chemotherapy, gonadotropin-releasing hormone agonist therapy, and palliative radiation therapy, but her disease progressed.

Conclusion

Aggressive endometriosis raises important diagnostic and therapeutic difficulties and may correspond to misdiagnosed rare malignant neoplasms, which should be treated.

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Condition tags

endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Endometrial Neoplasms Endometriosis Sarcoma, Endometrial Stromal Sciatic Nerve Biopsy, Needle Cell Transformation, Neoplastic Combined Modality Therapy Disease Progression Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Fatal Outcome Female Humans Immunohistochemistry Laparotomy Magnetic Resonance Imaging Middle Aged

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Cited by (22)

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