The effect of ENEAS application in patients with endometriosis and its influence on the level of IL-8 and MCP-1

Denghui Liang, Ping Zang, Yuhong Zhang, Jun Xue, Yan Wang, Lihua Chen, Jun Zhang, Lisha Shu, Ying He, Hui Ma, Mei Qiao, Na Wang
Cellular and molecular biology (Noisy-le-Grand, France) · 2022 · vol. 67(4) , pp. 334–339 · doi:10.14715/cmb/2021.67.4.38 · PMID:35809271 · W4205490011
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study evaluated the Enhanced Endometriosis Archiving Software (ENEAS) in 100 endometriosis patients, finding significantly reduced IL-8 gene expression in the ENEAS group compared to the control group.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper evaluated whether using Enhanced Endometriosis Archiving Software (ENEAS) in 100 women with endometriosis affected inflammatory chemokine gene expression, specifically IL-8 and MCP-1. Participants were divided into two groups of 50: a control group received gynecologist examination with medication and treatment, while the case group had demographic and clinical information entered into ENEAS, with IL-8 and MCP-1 gene expression assessed from blood RNA after extraction and cDNA synthesis. The authors found that IL-8 gene expression was significantly reduced in the ENEAS/case group versus control (P = 0.035), while MCP-1 expression also decreased but without statistical significance. The paper does not clearly state broader methodological limitations beyond the described design, and it does not elaborate on how ENEAS itself causally impacts biology versus acting as part of a broader workflow. This paper is centrally about endometriosis — it studies ENEAS application and its association with IL-8 and MCP-1 gene expression changes in women with endometriosis.

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Abstract

Endometriosis is a gynecological disease that endometrial cells develop outside the uterus. This event happens when the endometrial glands grow outside the endometrium and uterine muscles, especially in the pelvis. Although endometriosis is widespread, the clinical manifestations of the disease are very different, and it is challenging to adapt to the conventional classification system to divide patients into homogeneous groups. Given the importance of endometriosis, a correct, accurate, and timely diagnosis of this disease can significantly prevent its complications. Using health-related software is one of these ways. Enhanced Endometriosis Archiving Software (ENEAS) is a web-based application based on one of the most widely used open-source database management systems (MySQL), allowing the direct link to other open-source software for data management and storage. In the current study, the effect of ENEAS application was considered in patients with endometriosis, and its influence on IL-8 and MCP-1 gene expression was evaluated. For this purpose, 100 women with endometriosis were divided into two groups of 50 patients. The first group (control group) was examined by a gynecologist and received medication and treatment. In the case group, their demographic and clinical information were entered into ENEAS software. To study the expression of the IL-8 gene and MCP-1 gene, after collecting 5 ml of blood samples in tubes containing anticoagulant, RNA extraction was performed by Total RNA Purification Kit (Cat. 17200, 37500, 17250). Then cDNA synthesis was performed for this purpose, and a Bioneer DNA synthesis kit (South Korea) was used. The results showed that the expression level of the IL-8 gene in the case group was significantly reduced compared to the control group (P = 0.035). MCP-1 gene expression was also decreased compared to the control group, but this decrease was not significant. Therefore, those who used this application for treatment had reduced expression of IL-8 and MCP-1 genes. This event indicates that this application has reduced the amount of inflammation caused by endometriosis with proper analysis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Female Female Female Female Female

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