The role of apurinic/apyrimidinic endonuclease DNA repair gene in endometriosis.

Hsu CM, Chin Mu Hsu, Chin-Mu Hsu, Wen Shin Chang, Wen-Shin Chang, Chang WS, Jeng-Jong Hwang, Hwang JJ, Jeng Jong Hwang, Ju Yu Wang, Ju-Yu Wang, Wang JY, Hsiao YL, Yun Lin Hsiao, Yun-Lin Hsiao, Chia Wen Tsai, Chia-Wen Tsai, Tsai CW, Juhn Cherng Liu, Juhn-Cherng Liu, Liu JC, Tsung-Ho Ying, Tsung Ho Ying, Ying TH, Bau DT, DA-Tian Bau, Da Tian Bau
Cancer genomics & proteomics · 2015 · vol. 11(6) , pp. 295–301 · PMID:25422360 · W2183865629
article OA: closed CC0 ⤵ 3 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study found no association between the APEX1 Asp(148)Glu genotype and endometriosis risk, nor did it find that this genotype correlated with APEX1 mRNA or protein levels in endometriosis tissues.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND/AIM: The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. PATIENTS AND METHODS: In the current case-control study, 153 endometriosis patients and 636 non-endometriosis controls were recruited. APEX1 Asp(148)Glu (rs1130409) genotyping was conducted by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). At the same time, twenty eight endometriosis tissue samples with different genotypes were examined regarding their expression levels of APEX1 mRNA and protein by quantitative reverse transcription-polymerase chain reaction (q-PCR) and western blotting, respectively. RESULTS: Compared with wild-type TT genotype, TG and GG genotypes of APEX1 Asp(148)Glu had a risk of endometriosis of 0.93- and 0.87-fold. The results from in vivo transcriptional (RNA) and translational (protein) level analysis revealed that the APEX1 mRNA and protein were of similar levels among the endometriosis tissues of people carrying TT, TG, or GG genotypes. There was no joint effect of APEX1 Asp(148)Glu genotype with menarche, pregnancy, smoking or alcohol drinking lifestyles on endometriosis risk. CONCLUSION: The APEX1 Asp(148)Glu genotype correlates well with its mRNA and protein expression among endometriosis patients and may not serve as a sensitive marker for prediction of endometriosis risk in Taiwan.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

DNA-(Apurinic or Apyrimidinic Site) Lyase DNA Repair Endometriosis Endometriosis Genetic Predisposition to Disease Adult Alcohol Drinking Alcohol Drinking Amino Acid Substitution Case-Control Studies DNA-(Apurinic or Apyrimidinic Site) Lyase DNA Repair Endometriosis Female Gene Expression Regulation Humans Menarche Menarche Pregnancy Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Cited by (3)

Source provenance

europepmc
last seen: 2026-09-08T06:17:11.951632+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:18:10.358439+00:00
License: CC0 · commercial use OK