The Origin of Ovarian Cancer — Is It Getting Clearer?

Michael J Birrer
The New England journal of medicine · 2010 · vol. 363(16) , pp. 1574–1575 · doi:10.1056/nejme1009527 · PMID:20942676 · W1987274840
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This paper reviews the documented association between endometriosis and an increased risk of clear-cell and endometrioid ovarian carcinomas, while noting the early development of these cancers remains poorly defined.

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Abstract

The association of endometriosis and ovarian cancer was first reported by Sampson in 1925.1 Transitional areas of endometriosis, ranging from benign to atypical, adjacent to ovarian cancer have been well documented.2 The risk of ovarian cancer among women with endometriosis is higher, by 30 to 40%, than among women without endometriosis. The vast majority of ovarian cancers associated with endometriosis are clear-cell or endometrioid carcinomas. The early development of ovarian cancer remains poorly defined. Historically, most attention has been focused on serous adenocarcinoma, the most common and lethal histologic type. These tumors have been thought to arise from the surface . . .

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Mutation Nuclear Proteins Ovarian Neoplasms Transcription Factors Adenocarcinoma, Clear Cell DNA-Binding Proteins Endometriosis Endometriosis Female Gene Expression Profiling Humans Nuclear Proteins Ovarian Neoplasms Transcription Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (12)

Cited by (9)

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