Cytokines in the peritoneal fluid of patients with endometriosis

Koyama N, N. Koyama, K. Matsuura, Matsuura K, Hitoshi Okamura, Okamura H, H Okamura
International Journal of Gynecology & Obstetrics · 1993 · vol. 43(1) , pp. 45–50 · doi:10.1016/0020-7292(93)90273-y · PMID:7904954 · W2091352452
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This study found elevated levels of IL-5 and IL-6 in the peritoneal fluid of endometriosis patients, with a negative correlation between IL-5 and IL-6.

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Abstract

OBJECTIVE: To determine which of the various cytokines interleukin-5 (IL-5), interleukin-6 (IL-6) and interleukin-1 (IL-1) are important in endometriosis. METHODS: Peritoneal fluid (PF) samples were taken from 55 women at the time of either laparotomy or laparoscopy, and were examined for the levels of IL-5, IL-6 and IL-1 using each cytokine specific sandwich enzyme-linked immunosorbent assay. Thirty-two patients had pelvic endometriosis, eight post-pelvic inflammatory disease, four advanced cancer, three adenomyosis, three benign ovarian tumor, and other diseases. Statistical analysis was performed with the Mann Whitney test, chi-square test or Fisher's test. RESULTS: Both IL-5 and IL-6 levels in PF specimens with endometriosis tended to be higher than normal, while the same specimens were mostly interleukin-1 beta (IL-1 beta) negative. Of great interest was the negative correlation between log (IL-5) and IL-6 (Fisher's test, P < 0.04). CONCLUSION: These findings support the concept that IL-5 and IL-6 but not IL-1 are associated with endometriosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Cytokines Cytokines Cytokines Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Humans Humans Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (22)

Cited by (50)

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