Pregnancy Rate after Controlled Ovarian Hyperstimulation and Intrauterine Insemination for the Treatment of Endometriosis following Surgery

Attila Keresztúri, Zoltán Kozinszky, Zoltan Kozinszky, J. Daru, József Daru, Norbert Pásztor, János Sikovanyecz, János Zádori, Virág Márton, S Koloszár, Sándor Koloszár, János Szöllõsi, János Szöllősi, Gábor Németh
BioMed research international · 2015 · vol. 2015 , pp. 1–8 · doi:10.1155/2015/282301 · PMID:26247014 · PMC4515270 · W1585770880
article OA: gold CC0 ⤵ 10 in-corpus citations
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Controlled ovarian hyperstimulation and intrauterine insemination after laparoscopic endometriosis treatment yielded a 53.4% pregnancy rate, significantly higher than surgery alone.

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Abstract

OBJECTIVE: To compare pregnancy rate after controlled ovarian hyperstimulation and intrauterine insemination (COH-IUI) with no treatment in patients with endometriosis-associated infertility treated with laparoscopy. DESIGN: A clinical cohort study. SETTING: University-level tertiary care center. PATIENTS: 238 women with various stages of endometriosis after laparoscopic treatment. INTERVENTIONS: Either COH-IUI or follow-up for 12 months. MAIN OUTCOME MEASURES: The primary outcome measures were clinical pregnancy and live birth rate. Predictive factors evaluated were female age, maternal BMI, and duration of infertility. RESULTS: The pregnancy rate attained after the integrated laparoscopy-COH-IUI approach was 53.4%, while it was significantly lower (38.5%) in the control group. Similarly, a significant difference was observed in live births (48.3% versus 34.2%). Patients with severe endometriosis were less likely to achieve pregnancy (38%) and live birth (35%) than their counterparts with milder forms (57% and 53%). CONCLUSIONS: In patients with endometriosis-based infertility, surgery followed by COH-IUI is more effective than surgery alone.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility Insemination, Artificial Ovulation Induction Pregnancy Rate Adult Age Distribution Cohort Studies Combined Modality Therapy Combined Modality Therapy Comorbidity Endometriosis Female Humans Hungary Hungary Infertility Infertility Insemination, Artificial

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