Des pistes de réflexion pour la recherche sur l’endométriose en France

Jean Rosenbaum, Nicolas Bourdel, Saadi Khochbin, Marina Kvaskoff, Sachiko Matsuzaki, Fatima Mechta‐Grigoriou, Nicola Pluchino, Olivier Sandra, Daniel Vaiman
Medecine sciences : M/S · 2022 · vol. 38(3) , pp. 274–279 · doi:10.1051/medsci/2022027 · PMID:35333164 · W4220652710
article OA: hybrid CC0
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper proposes avenues for endometriosis research in France, emphasizing the need to engage related scientific communities to better understand this poorly understood disease affecting 10% of women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This French overview by Rosenbaum and colleagues discusses what should be prioritized for endometriosis research, noting that the disease is chronic, heterogeneous, and incompletely understood, with prevalence estimated around 10% of women of reproductive age and substantial quality-of-life and health-system costs. It synthesizes high-level evidence gaps and methodological challenges in epidemiology, including the difficulty of estimating true prevalence/incidence and potential bias from long delays between symptom onset and diagnosis (about 7 years on average), which can create reverse causation for retrospective risk factors. The article highlights the need to define subtypes, understand natural history, identify risk factors and comorbid groups, and better use patient samples and interdisciplinary collaborations; it also comments that emerging in vitro organoid models are promising but lack reproducibility and require added complexity (e.g., stromal and vascular components). It does not explicitly evaluate new original experimental or epidemiologic results, limiting its conclusions to research direction-setting. This paper is centrally about endometriosis — proposing research priorities for France and discussing key scientific and methodological needs for advancing endometriosis understanding.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

L’endométriose est une maladie chronique dans laquelle des lésions ressemblant à du tissu endométrial se retrouvent hors de l’utérus, principalement dans la cavité abdomino-pelvienne. Cette maladie pourrait toucher 10 % des femmes en âge de procréer. Elle est à l’origine d’une importante altération de la qualité de vie et d’un coût majeur pour le système de santé. Peu d’équipes de recherche sont mobilisées sur ce sujet, et la physiopathologie de la maladie reste mal comprise. Nous proposons dans cet article des pistes de réflexion pour la recherche sur l’endométriose en France, fondées notamment sur la mobilisation de communautés scientifiques connexes (notamment celles impliquées dans la recherche sur le cancer, la biologie du développement, l’épigénétique, les neurosciences).

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-25T00:34:59.361552+00:00
License: CC0 · commercial use OK