Endometriosis. Current issues in diagnosis and medical management.

Brosens Ia, I A Brosens
The Journal of reproductive medicine · 1998 · vol. 43(3 Suppl) , pp. 281–6 · PMID:9564662 · W2417404179
article OA: closed CC0 ⤵ 18 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study analyzed endometriosis morphology and medical therapy effects, finding that functional activity is key and medical treatments reduce pain by preventing cyclic bleeding in implants, causing regression but not elimination.

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Abstract

OBJECTIVE: To explore the hypothesis that endometriosis is a disease not just because it exists but because it is functionally active. STUDY DESIGN: Qualitative research analyzing the morphologic appearances of endometriosis and the clinical effect of medical therapies. RESULTS: Analysis of the appearances of symptomatic endometriosis demonstrates that the ectopic endometriumlike tissue mimics eutopic endometrium but with loss of polarization. Ectopic implants resembling superficial endometrium are hemorrhagic and associated with adhesion and pseudocyst or endometrioma formation. Ectopic implants resembling basal or junction zone endometrium are associated with nodular adenomyotic lesions in the posterior fornix and pelvic supportive structures. They are characterized by smooth muscle hyperplasia and T-lymphocyte aggregates. CONCLUSION: Medical therapy has been shown to be very efficient in reducing pelvic pain as soon as amenorrhea is created and maintained. Regression, but not elimination, of the implant is obtained by medical therapy. Clinical data support the hypothesis that the efficacy of medical therapy is largely achieved by preventing cyclic bleeding in the implants.

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Condition tags

endometriosischronic_pelvic_painendometrioma

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Amenorrhea Choristoma Choristoma Endometrium Endometrium Endometrium Female Humans Ovarian Diseases Ovarian Diseases Pelvic Pain Pelvic Pain Pelvic Pain Peritoneal Diseases Peritoneal Diseases Rectal Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (18)

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