Near-Infrared Imaging with Indocyanine Green for Detection of Endometriosis Lesions (Gre-Endo Trial): A Pilot Study

Francesco Cosentino, Giuseppe Vizzielli, Luigi Carlo Turco, Anna Fagotti, Fagotti A, Stefano Cianci, Gian Franco Zannoni, Virginia Vargiu, Zannoni G.F., Gabriella Ferrandina, Giovanni Scambia, Ferrandina G
Journal of Minimally Invasive Gynecology · 2018 · vol. 25(7) , pp. 1249–1254 · doi:10.1016/j.jmig.2018.02.023 · PMID:29551477 · W2793423020
article OA: closed CC0 ⤵ 35 in-corpus citations
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This pilot study investigated the efficacy of near-infrared imaging with indocyanine green for detecting endometriosis lesions.

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Abstract

Study objectiveTo evaluate near-infrared radiation imaging with intravenous indocyanine green (NIR-ICG) during laparoscopic intervention to identify endometriosis lesions.DesignA single-center, prospective, single-arm pilot study (Canadian Task Force classification II-2).SettingAn academic tertiary care and research center.PatientsTwenty-seven patients with symptomatic endometriosis were enrolled.InterventionsPatients underwent laparoscopic surgery using a laparoscopic system prototype with NIR-ICG.Measurements and main resultsA total of 116 suspected endometriosis lesions were removed from 27 patients. One hundred lesions had already been visualized in white light imaging by an expert surgeon; the remaining 16 were detected and removed using NIR-ICG. A total of 111 specimens were positive for endometriosis pathology. Positive predictive value of 95% and 97.8% and negative predictive value of 86.2% and 82.3% were found by white light imaging and NIR-ICG, respectively, with sensitivity of 85.6% and 82% and specificity of 95.2% and 97.9%, respectively.ConclusionNIR-ICG may be a tool for intraoperative diagnosis, confirmation of visible endometriosis lesions, and a marker for identifying occult endometriosis. Further prospective studies with a larger population sample are warranted to validate these encouraging preliminary results.

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Condition tags

endometriosis

MeSH descriptors

Coloring Agents Endometriosis Indocyanine Green Spectroscopy, Near-Infrared Adult Coloring Agents Endometriosis Endometriosis Endometriosis Female Humans Indocyanine Green Laparoscopy Laparoscopy Middle Aged Pilot Projects Predictive Value of Tests Prospective Studies Sensitivity and Specificity Young Adult

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