Indocyanine green in the surgical management of endometriosis: A systematic review

Manuel M Ianieri, Manuel Maria Ianieri, Luigi Della Corte, Federica Campolo, Francesco Cosentino, Ursula Catena, Giuseppe Bifulco, Giovanni Scambia
Acta obstetricia et gynecologica Scandinavica · 2020 · vol. 100(2) , pp. 189–199 · doi:10.1111/aogs.13971 · PMID:32895911 · W3048310184
review OA: bronze CC0 ⤵ 17 in-corpus citations
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This systematic review of 17 studies found near-infrared indocyanine green useful for evaluating vascularization after deep infiltrating endometriosis surgery but had inconsistent results for lesion detection.

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Abstract

INTRODUCTION: Endometriosis is a very common disease that affects up to 10% of the female population. The use of indocyanine green (ICG) dye has been proposed to allow the proper localization of endometriotic lesions during surgery. Our purpose is to offer an overview of near-infrared (NIR)-ICG in the surgical treatment of superficial peritoneal endometriosis and deep infiltrating endometriosis. MATERIAL AND METHODS: Electronic databases were searched, including MEDLINE, Embase, Web of Science, Scopus, ClinicalTrial.gov, OVID and Cochrane Library. The studies were identified with the use of a mesh combination of the following keywords: "indocyanine green", "endometriosis", "deep endometriosis", "robotic surgery", "laparoscopy", "ureter", "rectosigmoid" from 2000 to May 2020. All articles describing the use of ICG applied to endometriosis surgery were considered for review. Only original papers that reported specific experience data on the topic were included. Moreover, video-articles were included in the analysis. Quality and risk of bias were evaluated by two authors, respectively. RESULTS: Fifty-three studies were reviewed and reviews or comment articles not reporting original data and original articles lacking specific data on the application of ICG in patients affected by endometriosis were excluded. The quality of the 17 studies included was assessed. Eight studies suggested the usefulness of NIR-ICG as a tool in the detection of endometriosis during surgery, and one randomized controlled trial and one prospective study did not confirm the advantage of its use. Eight studies found that NIR-ICG was useful for the evaluation of vascularization in intestinal anastomoses and ureterolysis after surgery for deep infiltrating endometriosis. CONCLUSIONS: NIR-ICG appears useful in the evaluation of vascularization in intestinal anastomoses after segmental resection, confirming its role even after ureterolysis for parametrial deep infiltrating endometriosis. However, its usefulness as a tool in the detection of endometriosis during surgery is inconsistent.

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Condition tags

mesh:D004715endometriosisdie_deep_infiltrating

MeSH descriptors

Coloring Agents Endometriosis Endometriosis Indocyanine Green Surgery, Computer-Assisted Endometriosis Female Humans Intestinal Diseases Intestinal Diseases Intestinal Diseases Laparoscopy Optical Imaging Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Robotic Surgical Procedures Spectroscopy, Near-Infrared Ureteral Diseases Ureteral Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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