Comprehensive Review of Fluorescence Applications in Gynecology

Joanna Polom, Joanna Połom, Leszek Kalinowski, Michèle Diana, Manish Chand, Carmela Caballero, Sambor Sawicki, Karol Połom, Karol Polom
Journal of clinical medicine · 2021 · vol. 10(19) , pp. 4387 · doi:10.3390/jcm10194387 · PMID:34640405 · PMC8509149 · W3204902068
review OA: gold CC0 ⤵ 2 in-corpus citations
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Abstract

Since the introduction of indocyanine green (ICG) as a fluorophore in near-infrared imaging, fluorescence visualization has become an essential tool in many fields of surgery. In the field of gynecology, recent new applications have been proposed and found their place in clinical practice. Different applications in gynecology were investigated, subcategorized, and overviewed concerning surgical applications and available dyes. Specific applications in which fluorescence-guided surgery was implemented in gynecology are described in this manuscript-namely, sentinel node biopsy, mesometrium visualization, angiography of different organs, safety issues in pregnant women, ureters visualization, detection of peritoneal metastases, targeted fluorophores for cancer detection, fluorescent contamination hysterectomy, lymphography for lower limb lymphedema prevention, tumor margin detection, endometriosis, and metastases mapping. With evolving technology, further innovative research on the new applications of fluorescence visualization in cancer surgery may help to establish these techniques as standards of high-quality surgery in gynecology. However, more investigations are necessary in order to assess if these innovative tools can also be effective to improve patient outcomes and quality of life in different gynecologic malignancies.

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