High-dose pilot study with the novel progestogen dienogestin patients with endometriosis
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High-dose dienogest (20 mg/day) effectively treated endometriosis, including stage IV, with a favorable side-effect profile compared to other progestin therapies.
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Abstract
High-dose dienogest (20 mg/day) was used for the treatment of endometriosis in women aged 18-52 years after laparoscopic and histological diagnosis of endometriosis and staging according to the revised American Fertility Society criteria. Treatment efficacy was analyzed objectively by second-look laparoscopy, and serum hormone measurements and evaluation of endometriosis-related symptoms were performed done and side-effects recorded. Compared with other high-dose progestin therapies, treatment with dienogest was shown to be effective even in stage IV endometriosis. The side-effect profile of the high-dose dienogest treatment appears to be highly favorable compared with other treatments. Neither the menopausal symptoms caused by therapy with gonadotropin-releasing hormone agonists nor the adverse androgen-related effects induced by danazol were observed. Therefore, long-term high-dose dienogest therapy can be recommended particularly for women with progressive endometriosis.
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References (19)
- A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis via openalex
- Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex
- Endometriosis: a clinically malignant disease via openalex
- Gonadotropin-releasing hormone agonists: treatment of endometriosis via openalex
- Influence of Dienogest on Ovulation in Young Fertile Women via openalex
- Long-term follow-up on the treatment of endometriosis with the GnRH-agonist buserelinacetate. Long-term follow-up data (up to 98 months) of 42 patients with endometriosis who were treated with GnRH-agonist buserelinacetate (Suprecur), were evaluated in respect of recurrence of pain symptoms and pregnancy outcome via openalex
- Management of endometriosis with oral medroxyprogesterone acetate via openalex
- Pain symptoms associated with endometriosis via openalex
- Pathophysiology, diagnosis and treatment of endometriosis via openalex
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex
- Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex
- [Results of long-term follow-up in treatment of endometriosis with the GnRH agonist leuprorelin acetate depot (Enantone-Gyn monthly depot)] via openalex
- Revised American Society for Reproductive Medicine classification of endometriosis: 1996 via openalex
- The Role of Medical Management in the Treatment of Endometriosis via openalex
- Treatment of endometriosis via openalex
- Treatment of endometriosis with estrogen-progestin combination and progestogens alone via openalex
- W4285719527 via openalex
- W2417044776 via openalex
- W2477008945 via openalex
Cited by (42)
- Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread 2024
- Dienogest in conjunction with GnRH-a for postoperative management of endometriosis 2024
- Hormonal Therapies before In-Vitro Fertilization in Women with Endometriosis 2024
- Adenosine deaminase family acting on RNA 1 may be a de novo target on endometriosis 2023
- A progestin isn't a progestin: dienogest for endometriosis as a blueprint for future research - Review as a contribution for discussion 2020
- CLINICAL CASE OF SUCCESSFUL TREATMENT OF INFERTILITY IN A PATIENT WITH FAILURE IVF RESULTS IN ANAMNESIS 2020
- Progestins in the Medical Management of Endometriosis 2017
- Dienogest Therapy as a Treatment for Catamenial Pneumothorax: Case Report and Review of Hormonal Options 2017
- The effect of genistein on TGF-β signal, dysregulation of apoptosis, cyclooxygenase-2 pathway, and NF-kB pathway in mice peritoneum of endometriosis model 2017
- Ureteral endometriosis: A systematic literature review 2017
- Efficacy and Safety of Long-Term Use of Dienogest in Women With Ovarian Endometrioma 2017
- Oral and depot progestin therapy for endometriosis: towards a personalized medicine 2017
- The combined approach (laparoscopy + dienogest) for endometrios-associated infertility treatment 2016
- From the history of studies of endometriosis to current treatments 2016
- The combined approach (laparoscopy + dienogest) for endometrios-associated infertility treatment 2016
- The effeciency of IVF protocols in patients with moderate to severe endometriosis after adjuvant therapy 2015
- Hormonal treatment for severe hydronephrosis caused by bladder endometriosis 2014
- Dienogest in the treatment of endometriosis 2014
- Ureteral endometriosis: proposal for a diagnostic and therapeutic algorithm with a review of the literature 2013
- Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E₂ production in human endometriotic stromal cells in spheroid culture 2012
- Diagnosis and treatment of bladder endometriosis: state of the art 2012
- Treatment of endometriosis in different ethnic populations: a meta-analysis of two clinical trials 2012
- Sequential Management with Gonadotropin-Releasing Hormone Agonist and Dienogest of Endometriosis-Associated Uterine Myoma and Adenomyosis 2012
- The use of an oral contraceptive containing estradiol valerate and dienogest before office operative hysteroscopy: a feasibility study 2012
- Evaluation of the effects of rifampicin, ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women 2012
- Dienogest in long-term treatment of endometriosis 2011
- Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain 2011
- Medical Therapies: Progestins 2011
- Medikamentöse Therapie der chronischen Endometriose 2011
- Why use of dienogest for the first contraceptive pill with estradiol? 2010
- Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system 2010
- Dienogest: a review of its use in the treatment of endometriosis 2010
- Dienogest: a new therapeutic agent for the treatment of endometriosis 2010
- Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study 2010
- Dienogest: an oral progestogen for the treatment of endometriosis 2010
- Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression 2009
- A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis 2009
- Dienogest and the breast 2009
- Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells 2007
- The value of two-step operative laparoscopy with interval pituitary suppression in the treatment of infertility caused by severe endometriosis 2007
- Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile 2007
- Emerging drugs in endometriosis 2006
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- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:03:37.664955+00:00
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