Tatsuto Notsu

No ORCID on file · 3 papers in corpus
article 2013
Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-α or interleukin-1β
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.10.038

ObjectiveDienogest (DNG), a selective P receptor (PR) agonist, is used to treat endometriosis. To investigate whether DNG affects nerve growth factor (NGF) expression, we stimulated human endometrial epithelial cells (hEECs) with inflammato…

article 2011
Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells
·doi:10.1016/j.fertnstert.2011.09.040

ObjectiveTo investigate the effect of dienogest on the expression of Toll-like receptor (TLR) 4 in human endometrial epithelial cells.DesignProspective basic research study.SettingPharmaceutical research center.Patient(s)None.Intervention(s…

article 2010
Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system
Steroids ·doi:10.1016/j.steroids.2010.08.010

Prostaglandin E(2) (PGE(2)) is a major mediator in the pathophysiology, and pathogenesis of gynecological diseases associated with abnormal endometrial disease with proliferation and inflammation, such as endometriosis. In this study, we in…