Unintended pregnancies with term delivery following ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroid and adenomyosis

Jae‐Seong Lee, Tae-Eung Kim, Jang Heub Kim, Byung Joon Park
In: Clinical and Experimental Obstetrics & Gynecology · 2018 · vol. 45(6) , pp. 842–844 · doi:10.12891/ceog4472.2018 · W3041194586
article OA: bronze CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Ultrasound-guided high-intensity focused ultrasound ablation for fibroids and adenomyosis resulted in 23 unintended pregnancies, with most achieving full-term delivery and no complications.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This clinical report assessed pregnancy outcomes in patients with uterine fibroid or adenomyosis treated with ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation, focusing on 23 unintended pregnancies that reached the follow-up period. Twelve pregnancies were reported to have no complications and continued to full term with uneventful vaginal or cesarean deliveries. Other outcomes included three spontaneous abortions and one preterm delivery, while five patients remained pregnant at the time of reporting. The paper cautions that safety for pregnancy remains uncertain due to the lack of large-scale studies and calls for well-designed prospective trials. This paper is centrally about adenomyosis and uterine fibroid — it reports term pregnancy outcomes after USgHIFU ablation in patients with adenomyosis.

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Abstract

Purpose of Investigation: This study aimed to assess the pregnancy outcome of patients with uterine fibroid or adenomyosis treated by ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation. Materials and Methods: Treatment was administrated using a focused ultrasound tumor therapeutic system. In this study, there were 23 unintended pregnancies after USgHIFU ablation. Results: Twelve patients developed no complication during pregnancy and continued until full term delivery. Vaginal and cesarean section deliveries were also uneventful. The following are the pregnancy outcome of the patients: three patients experienced spontaneous abortions, one patient experienced preterm delivery, and five patients remained pregnant at this point. Conclusions: USgHIFU seems to have the effectiveness to precisely treat adenomyosis and uterine fibroid, allowing for normal reproduction. Well-designed prospective trials are needed to ascertain the safety of this treatment with pregnancy due to the lack of large-scaled study.
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Abstract

Purpose of Investigation: This study aimed to assess the pregnancy outcome of patients with uterine fibroid or adenomyosis treated by ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation. Materials and Methods: Treatment was administrated using a focused ultrasound tumor therapeutic system. In this study, there were 23 unintended pregnancies after USgHIFU ablation. Results: Twelve patients developed no complication during pregnancy and continued until full term delivery. Vaginal and cesarean section deliveries were also uneventful. The following are the pregnancy outcome of the patients: three patients experienced spontaneous abortions, one patient experienced preterm delivery, and five patients remained pregnant at this point. Conclusions: USgHIFU seems to have the effectiveness to precisely treat adenomyosis and uterine fibroid, allowing for normal reproduction. Well-designed prospective trials are needed to ascertain the safety of this treatment with pregnancy due to the lack of large-scaled study.

Keywords

- Adenomyosis - HIFU - Pregnancy - Uterine fibroid

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adenomyosis

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