Studies on Prostaglandin Production Relating to the Mechanism of Dysmenorrhea in Endometriosis

Koike H, Hiroyuki Koike, H Koike, Tsuyomu Ikenoue, Ikenoue T, T Ikenoue, Norimasa Mori, Mori N, N. Mori
Nihon Naibunpi Gakkai zasshi · 1994 · vol. 70(1) , pp. 43–56 · doi:10.1507/endocrine1927.70.1_43 · PMID:7958083 · W2329093321
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⚙ AI-generated summary by claude@2026-06, 2026-06-28 ⓘ

This study found that prostaglandin production, particularly PGI2, is significantly elevated in endometriosis tissue and correlates with dysmenorrhea severity, suggesting PGI2 may induce hyperalgesia during menstruation.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

The study measured prostaglandin (PG) production in endometriosis and non-endometriosis ovarian and uterine tissues across the menstrual cycle, relating PG outputs to dysmenorrhea mechanisms. It found that adenomyosis tissues had higher PG production, especially 6-keto PGF1α during the secretory and menstrual phases, and that endometriosis-associated ovarian cyst tissues produced significantly more PGs than normal or non-endometriosis ovarian cyst tissues. In endometriosis, PG production showed a tendency to increase with stronger menstrual pain, with the most pronounced relationship between dysmenorrhea severity and 6-keto PGF1α in adenomyosis. This paper is centrally about endometriosis and adenomyosis mechanisms of dysmenorrhea via prostaglandin production.

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Abstract

The relationship between prostaglandins (PGs) production and the mechanism of dysmenorrhea in endometriosis is poorly understood. Consequently, we investigated the role of PGs in dysmenorrhea of endometriosis. Slices of normal endometrium, normal myometrium, adenomyosis, leiomyoma, normal ovary and affected ovary were incubated. 6-keto PGF1 alpha (a metabolite of PGI2), TXB2 (a metabolite of TXA2), PGF2 alpha and PGE2 concentrations of the incubation medium were measured by RIA. The results are as follows; 1) PGs production in endometriosis was significantly higher than that of other tissues, especially 6-keto PGF1 alpha, which was a dominant product in adenomyosis. 2) There were significant differences in PGs production between severe dysmenorrhea and non dysmenorrhea, especially tissue of adenomyosis with severe dysmenorrhea which produces large amounts of 6-keto PGF1 alpha. 3) There seems to be interaction between normal endometrium and normal myometrium with regard to 6-keto PGF1 alpha production. We concluded that increased PGI2 in the tissue of endometriosis seems to induce hyperalgesia during menstruation.
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子宮内膜症におけるprostaglandins産生と月経痛発来機序に関する研究 1994 年 70 巻 1 号 p. 43-56 詳細 抄録 子宮内膜症および非子宮内膜症の卵巣および子宮組織におけるPGs産生を月経周期別に測定して, 次の成績を得た。 1)子宮腺筋症では, PGsの産生が高く, 特に分泌期, 月経期の子宮腺筋症組織では6-keto PGF1αの産生が高かった。 2)子宮内膜症性卵巣嚢腫組織でのPGs産生は正常卵巣組織や非子宮内膜症性卵巣嚢腫組織でのそれよりも有意に高かった。 3)子宮内膜症では,月経痛が強くなるにつれて, PGs産生が高くなる傾向にあった。特に, 子宮腺筋症における月経痛の程度と6-keto PGF1αの産生との関係が著明であった。 4)子宮腺筋症の内膜は, 月経期, 増殖期, 分泌期とも正常子宮の内膜, 子宮平滑筋腫の内膜と比べてPGsの産生が高かった。 5)正常子宮内膜と正常子宮筋組織では6-keto PGF1α産生においてinteractionがみられた。 1)子宮腺筋症では, PGsの産生が高く, 特に分泌期, 月経期の子宮腺筋症組織では6-keto PGF1αの産生が高かった。 2)子宮内膜症性卵巣嚢腫組織でのPGs産生は正常卵巣組織や非子宮内膜症性卵巣嚢腫組織でのそれよりも有意に高かった。 3)子宮内膜症では,月経痛が強くなるにつれて, PGs産生が高くなる傾向にあった。特に, 子宮腺筋症における月経痛の程度と6-keto PGF1αの産生との関係が著明であった。 4)子宮腺筋症の内膜は, 月経期, 増殖期, 分泌期とも正常子宮の内膜, 子宮平滑筋腫の内膜と比べてPGsの産生が高かった。 5)正常子宮内膜と正常子宮筋組織では6-keto PGF1α産生においてinteractionがみられた。 © 一般社団法人 日本内分泌学会

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Condition tags

dysmenorrheaendometriosisadenomyosis

MeSH descriptors

Dysmenorrhea Endometriosis Prostaglandins 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Adult Dinoprost Dinoprost Dinoprostone Dinoprostone Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometrium Endometrium Epoprostenol Epoprostenol Female Humans

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