Endometriosis and obstetrics complications: a systematic review and meta-analysis

Fabrizio Zullo, Spagnolo E, Emanuela Spagnolo, Gabriele Saccone, Acunzo M, Miriam Acunzo, Serena Xodo, Xodo S, Marcello Ceccaroni, Vincenzo Berghella
Fertility and sterility · 2017 · vol. 108(4) , pp. 667–672.e5 · doi:10.1016/j.fertnstert.2017.07.019 · PMID:28874260 · W2751185666
Systematic review / meta-analysis OA: bronze CC0 ⤵ 155 in-corpus citations
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This systematic review and meta-analysis examined the association between endometriosis and various obstetrical complications.

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Abstract

OBJECTIVE: To evaluate the effect of endometriosis on pregnancy outcomes. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Women with or without endometriosis. INTERVENTION(S): Electronic databases searched from their inception until February 2017 with no limit for language and with all cohort studies reporting the incidence of obstetric complications in women with a diagnosis of endometriosis compared with a control group (women without a diagnosis of endometriosis) included. MEAN OUTCOME MEASURE(S): Primary outcome of incidence of preterm birth at <37 weeks with meta-analysis performed using the random effects model of DerSimonian and Laird to produce an odds ratio (OR) with 95% confidence interval (CI). RESULT(S): Twenty-four studies were analyzed comprising 1,924,114 women. In most of them, the diagnosis of endometriosis was made histologically after surgery. Women with endometriosis had a statistically significantly higher risk of preterm birth (OR 1.63; 95% CI, 1.32-2.01), miscarriage (OR 1.75; 95% CI, 1.29-2.37), placenta previa (OR 3.03; 95% CI, 1.50-6.13), small for gestational age (OR 1.27; 95% CI, 1.03-1.57), and cesarean delivery (OR 1.57; 95% CI, 1.39-1.78) compared with the healthy controls. No differences were found in the incidence of gestational hypertension and preeclampsia. CONCLUSION(S): Women with endometriosis have a statistically significantly higher risk of preterm birth, miscarriage, placenta previa, small for gestational age infants, and cesarean delivery.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Obstetric Labor Complications Pregnancy Complications Endometriosis Endometriosis Endometriosis Female Female Humans Humans Incidence Incidence Infant, Newborn Infant, Newborn Obstetric Labor Complications Obstetric Labor Complications Obstetric Labor Complications Pregnancy Pregnancy Pregnancy Complications

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (50)

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