Rizner TL

No ORCID on file · 4 papers in corpus
article 2024
The effect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms: A Mendelian randomization study
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2024.106482

Endometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic str…

other 2011
Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1
Journal of medicinal chemistry ·doi:10.1021/jm101104z

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is an enzyme that catalyzes NADPH-dependent reduction of the weak estrogen, estrone, into the most potent estrogen, estradiol, which exerts proliferative effects via the estrogen receptors.…

other 2009
Disturbed estrogen and progesterone action in ovarian endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2008.07.020

Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion. In the present study, we have examined the expression of 11 estrogen an…

review 2009
Estrogen metabolism and action in endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2009.03.022

Endometriosis is a complex estrogen-dependent disease that is defined as the presence of endometrial glands and stroma outside the uterine cavity. The etiology of endometriosis is multifactorial and includes complex interactions of genetic,…