Disturbed estrogen and progesterone action in ovarian endometriosis

Tina Smuc, Smuc T, Hevir N, Neli Hevir, Ribic-Pucelj M, Martina Ribic-Pucelj, Bettina Husen, Husen B, Thole H, Hubert Thole, Rizner TL, Tea Lanisnik Rizner
Molecular and cellular endocrinology · 2009 · doi:10.1016/j.mce.2008.07.020 · PMID:18762229
other OA: green public-domain-us ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometriosis tissue exhibits increased expression of enzymes that produce estradiol and inactivate progesterone, alongside altered estrogen receptor expression, suggesting dysregulated steroid hormone action.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

I can’t access the paper’s content because the provided text is a website anti-bot/proof-of-work page rather than the research article itself, so the study population, methods, results, and limitations are not available to summarize. As a result, I cannot verify what “Disturbed estrogen and progesterone action in ovarian endometriosis” specifically reports. The paper’s title indicates it focuses on ovarian endometriosis and altered estrogen/progesterone signaling, but without the actual text I cannot confirm the key findings or stated caveats. This paper is centrally about endometriosis — specifically ovarian endometriosis and disrupted estrogen and progesterone action.

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Abstract

Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion. In the present study, we have examined the expression of 11 estrogen and progesterone metabolizing enzymes and their corresponding receptors in samples of ovarian endometriomas and control endometrium. Expression analysis revealed significant up-regulation of enzymes involved in estradiol formation (aromatase, sulfatase and all reductive 17beta-hydroxysteroid dehydrogenases) and in progesterone inactivation (AKR1C1 and AKR1C3). Among the estrogen and progesterone receptors, ERalpha was down-regulated, ERbeta was up-regulated, and there was no significant difference in expression of progesterone receptors A and B (PRAB). Our data indicate that several enzymes of estrogen and progesterone metabolism are aberrantly expressed in endometriosis, which can lead to increased local levels of mitogenic estradiol and decreased levels of protective progesterone. Changes in estrogen receptor expression suggest that estradiol may also act via non-estrogen receptor-mediated pathways, while expression of progesterone receptors still needs further investigation.
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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogens Ovary Ovary Progesterone 17-Hydroxysteroid Dehydrogenases 17-Hydroxysteroid Dehydrogenases 20-Hydroxysteroid Dehydrogenases 20-Hydroxysteroid Dehydrogenases 3-Hydroxysteroid Dehydrogenases 3-Hydroxysteroid Dehydrogenases Adult Aldo-Keto Reductase Family 1 Member C3 Aromatase Aromatase Endometriosis Endometriosis Estrogen Receptor alpha Estrogen Receptor alpha Estrogen Receptor beta

Citation neighborhood (sparse)

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Cited by (1)

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Source provenance

europepmc
last seen: 2026-08-01T06:07:04.264727+00:00
pubmed
last seen: 2026-05-13T22:14:24.299271+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine