Models Including Serum CA-125, BMI, Cyst Pathology, Dysmenorrhea or Dyspareunia for Diagnosis of Endometriosis

Tamara Knific, Katja Vouk, Andrej Vogler, Joško Osredkar, Manuela Gstöttner, René Wenzl, Tea Lanišnik Rižner
Biomarkers in medicine · 2018 · vol. 12(7) , pp. 737–747 · doi:10.2217/bmm-2017-0426 · PMID:29865858 · W2805961823
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Diagnostic models incorporating serum CA-125, BMI, cyst pathology, and either dyspareunia or dysmenorrhea showed potential for noninvasive endometriosis diagnosis.

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Abstract

AIM: To evaluate preoperative levels of CA-125 and HE4 in patients with endometriosis-like symptoms and to construct diagnostic models. PATIENTS: Prospective case-control study included 124 endometriosis patients and 97 control patients. MATERIALS & METHODS: Logistic regression was used to construct diagnostic models based on serum biomarker levels and clinical data. RESULTS: A model with CA-125, BMI, information on cysts and dyspareunia had an area under the curve value of 0.836, sensitivity of 74.0% and specificity of 81.3%. The second model included CA-125, BMI, information on cysts and dysmenorrhea and had an area under the curve value of 0.819, sensitivity of 74.8% and specificity of 79.2%. CONCLUSION: Constructed models have the potential for noninvasive diagnosis of endometriosis, and might be translated into clinical practice after additional validation.

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Condition tags

dysmenorrheadyspareuniaendometriosis

MeSH descriptors

Body Mass Index CA-125 Antigen Cysts Dysmenorrhea Dyspareunia Endometriosis Models, Statistical Adult CA-125 Antigen Case-Control Studies Cysts Dysmenorrhea Dyspareunia Endometriosis Endometriosis Endometriosis Endometriosis Fallopian Tubes Fallopian Tubes Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (9)

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