Expression of estrogen and progesterone receptors and their mRNAs in ovarian endometriosis

Ryou Misao, R Misao, J Fujimoto, Jiro Fujimoto, Yoshihito Nakanishi, Y Nakanishi, T Tamaya
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 1996 · vol. 10(5) , pp. 303–310 · doi:10.3109/09513599609012816 · PMID:8915659 · W1975759876
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Ovarian endometriosis exhibits significantly lower expression of estrogen and progesterone receptors and their mRNAs compared to normal endometria, with altered receptor ratios potentially contributing to disease growth.

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Abstract

To discover the molecular mechanisms of estrogen-induced growth in ovarian endometriosis, the expression of estrogen and progesterone receptors and their mRNAs was investigated. The expression of estrogen and progesterone receptors and their mRNAs was significantly (p < 0.01) lower in endometriotic endometria than in normal endometria. The ratio of estrogen receptors: progesterone receptors was significantly (p < 0.01) higher in the endometriotic tissues than in normal proliferative- and secretory-phase endometria, as was the ratio of their respective mRNAs. These findings suggest that the absolute and relatively reduced number of estrogen receptors in ovarian endometriosis might cause the loss of control of estrogenic action, and that, furthermore, the relatively increased number of progesterone receptors might lead to an estrogen-dominant milieu, assisting in the development and growth of the ovarian endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Expression Ovarian Diseases Receptors, Estrogen Receptors, Progesterone RNA, Messenger Adult Endometriosis Endometrium Endometrium Female Humans Middle Aged Ovarian Diseases Receptors, Estrogen Receptors, Progesterone RNA, Messenger

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (4)

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