Steroid receptors in endometriosis

Target organs bind and retain steroids against a high concentration gradient. The presence of an intracellular steroid receptor is considered as a prerequisite for hormonal response. The existence of specific oestrogen-binding proteins in oestrogen target tissues was first described by Jensen and Jacobsen1, and a quantitative assay of oestrogen receptors (ER) was first performed by Toft and Gorski2. Since then, steroid receptors have been extensively studied (for review and references see Edwards et al. 3). The traditional steroid receptors are acid proteins, which are characterized by high steroid-specificity of the binding, high binding affinity to the ligand and limited binding capacity at near physiological concentrations of the ligand. They are found only in tissues sensitive to steroid hormones. For several years the steroid receptors were regarded as localized mainly to the cytoplasm, where they were thought to bind to the hormone. The steroid-receptor complex was then transported to the nucleus, where it bound the chromatin chain. Thus, initially most studies on steroid receptors were performed in cytosol. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

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In Roland, R., Chadha, D.R. and Willemsen, W.N.P. (eds.) Gonadotrophin Down-Regulation in Gynecological Practice, pp. 81–102. (New York: Alan R. Liss) Editor information Editors and Affiliations Rights and permissions Copyright information © 1991 Springer Science+Business Media Dordrecht About this chapter Cite this chapter Bergqvist, A. (1991). Steroid receptors in endometriosis. In: Thomas, E.J., Rock, J.A. (eds) Modern Approaches to Endometriosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3864-2_3 Download citation DOI: https://doi.org/10.1007/978-94-011-3864-2_3 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-5719-6 Online ISBN: 978-94-011-3864-2 eBook Packages: Springer Book Archive

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