c-myc protooncogene polypeptide expression in endometriosis
Other
OA: closed
CC0
⤵ 32 in-corpus citations
AI-generated summary
This study investigated c-myc protooncogene polypeptide expression in endometriosis and reported its findings.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
The c-myc protooncogene and its polypeptide product are important regulators of cell proliferation and differentiation, and ovarian steroids are believed to stimulate growth of various uterine cell types through altered expression of the c-myc gene. To determine whether c-myc expression may also be involved in the growth and development of endometriosis, we assessed c-myc expression in eutopic and ectopic endometrial tissue obtained from women undergoing surgery for endometriosis. Immunocytochemistry using a monoclonal antibody to the c-myc protein demonstrated positive staining of glandular and stromal cell nuclei, and cytoplasmic staining of glandular but not stromal cells in both eutopic and ectopic endometrium. These findings suggest that c-myc expression may be an important regulator of cell proliferation in endometriotic tissue.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (26)
- Dating the Endometrial Biopsy via openalex
- ENDOMETRIOSIS via openalex
- Endometriosis : contemporary concepts in clinical management via openalex
- Endometriosis: Pathogenesis, symptoms, and findings via openalex
- Endometriosis: role of ovarian steroids in initiation, maintenance, and suppression via openalex
- Estrogen and progesterone cytosol receptor concentration in endometriotic tissue and intrauterine endometrium via openalex
- Estrogen and progestin receptors in endometriosis lesions: comparison with endometrial tissue via openalex
- Histochemical localization of specific estrogen and progesterone binding in human endometrium and endometriotic tissue. A preliminary report via openalex
- Steroidal regulation of endometriosis tissue: lack of induction of 17 beta-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex
- The effect of estrone and progesterone on the growth of experimental endometriosis in rhesus monkeys via openalex
- The effect of pregnancy upon endometriosis via openalex
- W2009661034 via openalex
- W2022119180 via openalex
- W1978440762 via openalex
- W2034248536 via openalex
- W1973060838 via openalex
- W2064624330 via openalex
- W1942629554 via openalex
- W2085093642 via openalex
- W2091998150 via openalex
- W2122609109 via openalex
- W2130227763 via openalex
- W2139996627 via openalex
- W1847174723 via openalex
- W1826524642 via openalex
- W360657380 via openalex
Cited by (33)
- Prefoldin-5 Expression Is Elevated in Eutopic and Ectopic Endometriotic Epithelium and Modulates Endometriotic Epithelial Cell Proliferation and Migration In Vitro 2024
- RPLP1 Is Up-Regulated in Human Adenomyosis and Endometrial Adenocarcinoma Epithelial Cells and Is Essential for Cell Survival and Migration In Vitro 2023
- Targeting c-MYC: a potential non-hormonal therapeutic approach for endometriosis treatment 2023
- 60S acidic ribosomal protein P1 (RPLP1) is elevated in human endometriotic tissue and in a murine model of endometriosis and is essential for endometriotic epithelial cell survival in vitro 2019
- How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence 2019
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis 2018
- Correlation Between the Clinical Parameters and Tissue Phenotype in Patients Affected by Deep-Infiltrating Endometriosis 2016
- Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery 2015
- Molecular mechanisms underlying endometriosis pathogenesis revealed by bioinformatics analysis of microarray data 2015
- Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis 2015
- Severe teenage acne and risk of endometriosis 2014
- MicroRNAs and the pathogenesis of endometriosis 2012
- The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis 2012
- Endometriosis: Disease Classification and Behavior 2011
- The Early Genes c-fos and c-jun: Potential Targets to Modulate Estrogen Action in Endometriosis?: 2009
- The Early Genes c-fos and c-jun: Potential Targets to Modulate Estrogen Action in Endometriosis? 2009
- Hibridação Genômica Comparativa em Endometriose 2008
- Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large? 2006
- Augmented cell survival in eutopic endometrium from women with endometriosis: expression of c-myc, TGF-beta1 and bax genes 2005
- Endometrium from women with and without endometriosis, and peritoneal, ovarian and bowel endometriosis, show different c-kit protein expression 2005
- Genetics of endometriosis 2003
- Pathology of Non-Neoplastic Ovarian Enlargements 2003
- Heritability and molecular genetic studies of endometriosis 2002
- Molecular approach to common causes of female infertility 2002
- Prolactin receptor in human endometriotic tissues 2002
- Prolactin receptor in human endometriotic tissues 2002
- Emerging role of genomics in endometriosis research 2002
- Heritability and molecular genetic studies of endometriosis 2002
- Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis 2002
- Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization 1999
- Aromatase expression in endometriosis 1996
- Cytokine regulation of cellular proliferation in endometriosis 1994
- Enhanced expression of resident leukocyte interferon gamma mRNA in endometriosis 1993
Source provenance
- europepmc
- last seen: 2026-10-09T06:09:53.026058+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:04:05.892929+00:00
License: CC0
· commercial use OK