Evaluation of the Ki-67 Proliferation Index and Urocortin Expression in Women with Ovarian Endometriomas

Serenat Eriş Yalçın, Serenat Eris Yalcin, Irfan Ocal, İrfan Öcal, Yakup Yalçın, Yakup Yalcin, Halime Sen Selim, Halime Şen Selim, Melike Demir Çaltekin, Melike Demir Caltekin, Hüseyin Aydoğmuş, Huseyin Aydogmus, Sefa Kelekci, Sefa Kelekçi
The Eurasian journal of medicine · 2017 · vol. 49(2) , pp. 107–112 · doi:10.5152/eurasianjmed.2017.17070 · PMID:28638252 · W2624061952
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This study found that a higher Ki-67 proliferation index in women with ovarian endometriomas was associated with a statistically significant increase in recurrence risk.

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Abstract

OBJECTIVE: The reasons why endometriosis is more aggressive and invasive in some patients are unknown. Despite the importance of population-based clinically defined risk factors in the prediction of recurrence, biochemical markers obtained from the patient are more valuable for prediction on an individual basis. Therefore, the discovery of significant potential biomarkers could be useful to clinicians for shedding light on the pathogenesis of endometriosis and in the monitoring recurrence. MATERIALS AND METHODS: This study included 50 patients who underwent surgery for ovarian cysts that were diagnosed as endometrioma. The age of the patients, stage of the endometriosis, diameter and localization of endometriomas, type of surgery, and pre- and postoperative cancer antigen 125 (CA125) levels were compared between patients with and without recurrence. The archived pathology slides were stained with Ki-67 and anti-urocortin antibodies for reevaluation. By comparing the pathology parameters of the patients with and without recurrence, the association between these parameters and recurrence was investigated. RESULTS: The median Ki-67 proliferation index of the patients with recurrence (7.5±6.5) was statistically significant compared with that of the patients without recurrence (1±4) (p=0.003). The urocortin epithelial staining intensity and percentage were not found to be statistically significant in comparison. A statistically significant difference was determined between postoperative CA125 median levels of patients without recurrence (10±17.6) and those of patients with recurrence (29.9±18.1) (p=0.003). CONCLUSION: The Ki-67 proliferation index may be useful for predicting prognosis and recurrence risk.
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Vol. 58 No. 3 (2026): Eurasian Journal of Medicine (Continuous Publication) In progress Published: 2026-04-20 Open Access Time to First Decision 36 days The Eurasian Journal of Medicine is a peer reviewed, open access, online-only journal. The journal is the official publication of Atatürk University School of Medicine. The Eurasian Journal of Medicine is a continuously published journal in English. The journal has moved to continuous publication by volume from Volume 57. Articles are published in four issues per year, with each issue gradually filling throughout the year as new articles are published. Vol. 58 No. 3 (2026): Eurasian Journal of Medicine (Continuous Publication) In progress Published: 2026-04-20

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endometriosisendometrioma

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