Clinical predictors of postoperative recurrence in ovarian endometrioma: evaluation of follistatin expression

Candost Hanedan, Sefa Kelekçi
In: Journal of Medicine and Palliative Care · 2026 · vol. 7(2) , pp. 381–385 · doi:10.47582/jompac.1899461 · W7141834806
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This study identified advanced-stage disease and prior endometriosis surgery as clinical predictors of postoperative recurrence in ovarian endometrioma and investigated the association between epithelial follistatin expression and recurrence.

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This paper investigates clinical predictors of postoperative recurrence in women with ovarian endometrioma, with emphasis on evaluating follistatin expression as a potential biomarker. The study evaluates postoperative outcomes in an ovarian endometrioma population and relates measured follistatin expression and clinical factors to recurrence risk, aiming to identify predictors that could explain who is more likely to recur. A key limitation is that the provided text includes only the title and bibliographic/administrative information without methodological details, so the specific study design, assays, cohort size, and how recurrence was defined cannot be verified from the excerpt. This paper is centrally about endometriosis — specifically postoperative recurrence prediction in ovarian endometrioma using follistatin expression.

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Abstract

Aims: To evaluate clinical predictors of postoperative recurrence in ovarian endometrioma and to investigate the association between epithelial follistatin immunohistochemical expression and recurrence after surgery. Methods: This retrospective study included patients who underwent surgery for ovarian endometrioma between 2008 and 2013. Demographic, clinical, and surgical data and recurrence characteristics were analyzed. Follistatin expression in endometriotic glandular epithelial cells was assessed immunohistochemically using a binary scoring system (positive vs. negative). Factors associated with recurrence were evaluated statistically.Results: Fifty patients were included, and recurrence occurred in 24 (48%). Advanced-stage disease was significantly more common in patients with recurrence (66.7% vs. 30.8%, p=0.034), and previous endometriosis surgery was markedly higher in the recurrence group (50.0% vs. 3.8%, p
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References

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endometriosisendometrioma

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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