Serum CA 125 levels in patients with endometriosis: changes in CA 125 levels during menstruation.
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Serum CA 125 levels are elevated during menstruation in patients with endometriosis and adenomyosis, potentially improving detection rates.
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Abstract
We investigated serum CA 125 levels in 120 patients with benign gynecologic disease, and examined variations in CA 125 levels during the menstrual cycle in six normally cycling women. CA 125 levels were elevated transiently during menstruation, suggesting that blood samples taken during menstruation can give a false-positive result. Whereas the CA 125 values during the nonmenstrual part of the cycle were significantly higher in the patients with adenomyosis and advanced endometriosis (stages III and IV) than in those with a normal pelvis, there was no difference between the patients with mild endometriosis (stages I and II) and the normal-pelvis group. CA 125 levels during menstruation were significantly elevated, not only in women with adenomyosis and advanced endometriosis, but also in those with mild endometriosis, compared with those with a normal pelvis. These data suggest that the measurement of serum CA 125 during menstruation may increase the rate of detection of endometriosis over that in studies done during other phases of the cycle.
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Cited by (20)
- Biomarkers in endometriosis-associated pain 2021
- Endometriosis - Recent Advances, New Perspectives and Treatments 2021
- A CLINICO-PATHOLOGICAL STUDY ON ENDOMETRIOSIS WITH SPECIAL REFERENCE TO THE CD10 MARKER 2019
- Assessment of biomarkers in women with endometriosis-associated pain using the ENG contraceptive implant or the 52 mg LNG-IUS: a non-inferiority randomised clinical trial 2018
- Avaliação de biomarcadores em mulheres com endometriose e dor usuárias do implante liberador de etonogestrel ou sistema intrauterino liberador de levonorgestrel = Assessment of biomarkers among women with endometriosis-associated pain users of the etonogestrel-releasing contraceptive implant or 52-mg levonorgestrel releasing intrauterine system: randomized clinical trial 2018
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Diagnostic accuracy of Cancer Antigen 125 (CA125) for endometriosis in symptomatic women: A multi-center study 2016
- Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis 2015
- The Incidence and Clinical Significance of Adenomyosis 2015
- The levonorgestrel-releasing intrauterine device reduces CA-125 serum levels in patients with endometriosis 2006
- Endometriosis and Systemic Lupus Erythematosus: A Comparative Evaluation of Clinical Manifestations and Serological Autoimmune Phenomena 2005
- Endométriose rénale. À propos d'un cas 2001
- Drastic elevation of serum CA125, CA72-4 and CA19-9 levels during menses in a patient with probable endometriosis 1998
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis 1998
- CA 125 in Benign Gynecological Conditions 1998
- Serum CA 125 levels before, during and after treatment for endometriosis 1995
- Screening transvaginal ultrasonography of postmenopausal women in a private office setting 1994
- Serum CA-125 concentration in endometriosis patients: Role of pelvic and peritoneal irritation 1994
- Screening transvaginal ultrasonography of postmenopausal women in a private office setting 1994
- CA 125 in the management of endometriosis 1993
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