The Level of Ca125 in Preand Postoperative of Endometriosis

Asriyanti Amsir, Andi Mardiah Tahir, Nusratuddin Abdullah
In: Indonesian Journal of Obstetrics and Gynecology · 2017 · pp. 142–146 · doi:10.32771/inajog.v4i3.436 · W2940096356
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This study found that preoperative and postoperative CA-125 levels were significantly higher in patients with stage III-IV endometriosis compared to stages I-II.

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This cross-sectional study measured serum CA-125 levels in patients with endometriosis undergoing laparoscopy or laparotomy, comparing preoperative versus postoperative values and assessing correlations with endometriosis stage and dysmenorrhea severity. Preoperative CA-125 was lower in stage I–II (mean 21.53 IU/ml) than stage III–IV (72.52 IU/ml), and postoperative CA-125 also differed by stage (14.82 vs 61.03 IU/ml), with both contrasts statistically significant (p<0.001). The study reported significant correlations between CA-125 and endometriosis stage (r=0.43–0.52) and between dysmenorrhea severity and stage (r=0.318–0.537), but it provides limited methodological detail on sample size and timing of postoperative sampling as stated in the abstract. This paper is centrally about endometriosis — it quantifies pre- and postoperative CA-125 levels and their relationship to disease stage and dysmenorrhea severity.

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Abstract

Objective: To determine the Ca-125 level in pre- and post-operative of endometriosis and its correlation to endometriosis stage and severity of dysmenorrhea. Method: This was a cross-sectional study design conducted at Dr. Wahidin Sudirohusodo dan some affiliated hospitals. We took the patients undergoing laparoscopy or laparotomy consecutively. Result: The mean value of preoperative Ca-125 level in stage I-II was 21.53 (SD 12.64) IU/ml vs 72.52 (SD 8.52) IU/ml in stage III-IV. The mean value of postoperative Ca-125 level was 14.82 (SD 10.00) IU/ml (stage I-II) vs 61.03 (SD 8.43) IU/ml (stage III-IV); they were significantly different (p
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The Level of Ca125 in Preand Postoperative of Endometriosis DOI: https://doi.org/10.32771/inajog.v4i3.436Abstract Objective: To determine the Ca-125 level in pre- and post-operative of endometriosis and its correlation to endometriosis stage and severity of dysmenorrhea. Method: This was a cross-sectional study design conducted at Dr. Wahidin Sudirohusodo dan some affiliated hospitals. We took the patients undergoing laparoscopy or laparotomy consecutively. Result: The mean value of preoperative Ca-125 level in stage I-II was 21.53 (SD 12.64) IU/ml vs 72.52 (SD 8.52) IU/ml in stage III-IV. The mean value of postoperative Ca-125 level was 14.82 (SD 10.00) IU/ml (stage I-II) vs 61.03 (SD 8.43) IU/ml (stage III-IV); they were significantly different (p<0.001). There was a significant correlation between Ca-125 level and the stage of endometriosis (r=0.43 and 0.52; p=0.005). We observed mild to severe dysmenorrhea for stage I-II; while, patients had moderate to severe dysmenorrhea in stage III-IV (p<0.001) and both of them showed a significant correlation (r=0.318 and 0.537; p<0.05). The Ca-125 level in stage I-II endometriosis was lower than stage III-IV. Conclusion: Level of Ca-125 will decrease after endometriosis surgery. There is a strong correlation between preoperative level of Ca-125 and endometriosis stage. The severity of dysmenorrhea has the correlation to the stage of endometriosis. Keywords: Ca-125, dysmenorrhea, endometriosisDownloads Download data is not yet available. Downloads Published 2016-07-26 Versions How to Cite Amsir, A., Tahir, A. M., & Abdullah, N. (2016). The Level of Ca125 in Preand Postoperative of Endometriosis. Indonesian Journal of Obstetrics and Gynecology, 4(3), 142–146. https://doi.org/10.32771/inajog.v4i3.436 Issue Section Research Article

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endometriosisdysmenorrhea

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