Non-Hormonal Therapy for Endometriosis Based on Angiogenesis, Oxidative Stress and Inflammation.
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This review explores non-hormonal therapies for endometriosis by examining their impact on angiogenesis, oxidative stress, and inflammation, key factors in the disease's pathophysiology.
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Abstract
Endometriosis is a common gynecological disease that occurs in between 6 and 10% of women who are at reproductive maturity. The presence of endometrial tissue outside the uterine cavity is the defining characteristic of this disease. Although the etiology of endometriosis remains controversial, there is a general consensus that multiple biological processes such as angiogenesis and vasculogenesis, oxidative stress, and inflammation contribute to its complex pathophysiology. Patients' expectations and priorities influence the treatment plan that is selected. For instance, therapy with hormone medications is inappropriate for endometriosis patients who wish to become pregnant since these medications interfere with ovulation. On the other hand, considering that the current endometriosis treatments are associated with recurrence of pain and disease despite the treatment of the disease and have many side effects, the design and application of non-hormonal drugs in this field is very necessary. Therefore, in this article, we tried to have an overview on non-hormonal treatments by considering angiogenesis, oxidative stress, and inflammation as important biological processes involved in endometriosis.
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Cites (3)
- Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. 2006
- Curcumin inhibits endometriosis endometrial cells by reducing estradiol production. 2013
- Chronic pelvic pain, quality of life and sexual health of women treated with palmitoylethanolamide and α-lipoic acid. 2015
Cited by (2)
References (4)
- Chronic pelvic pain, quality of life and sexual health of women treated with palmitoylethanolamide and α-lipoic acid. via openalex
- Curcumin inhibits endometriosis endometrial cells by reducing estradiol production. via openalex
- Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. via openalex
- W2130539656 via openalex
Cited by (2)
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pmc
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- pubmed
- last seen: 2026-06-02T00:32:20.209032+00:00
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