Role of Macrophage Migration Inhibitor Factor in Endometriosis

HU Yuhong, Jian Li, Sadichha Thapa
In: Archives of Medicine · 2015 · vol. 7(5) · W2180381244
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Macrophage migration inhibitor factor (MIF) is increased in endometriosis patients and plays a crucial role in disease pathology, pelvic pain, and infertility.

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Abstract

Endometriosis is a common gynecological disease among women of reproductive age, which affects approximately 6 ~10 percent of females, but the pathogenesis of endometriosis is still ambiguous. Until now, the prevailing theory concerning the etiology of endometriosis is the retrograde menstruation hypothesis put forward by Sampson in 1921. However, it can’t illustrate completely the etiology and pathology of the endometriosis. In recent years, immune-inflammatory factor is a hot point of endometriosis field. Many studies demonstrated that the numbers and level of cytokines in the peritoneal fluid of endometriosis patients, namely the macrophage migration inhibitor factor (MIF) which is one of the cytokines described previously, is increased. This has been observed to have a crucial role during the pathology of endometriosis as well as pelvic pain and infertility which are responsible for endometriosis. Therefore, MIF might be the target of new approach to diagnosis and therapy endometriosis.

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endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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