The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients

NurIedil Baharuddin, Nusratuddin Abdullah, Telly Tessy, St. Maisuri T. Chalid
In: Indonesian Journal of Obstetrics and Gynecology · 2018 · pp. 104 · doi:10.32771/inajog.v6i2.770 · W2889327513
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Matrix metalloproteinase-2 (MMP-2) levels in serum and peritoneal fluid were significantly higher in endometriosis patients and correlated with disease stage.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional study investigated the role of matrix metalloproteinase-2 (MMP-2) in serum and peritoneal fluid from endometriotic patients versus controls, enrolling 50 participants in hospitals in Makassar from May 2015 to May 2016 and measuring MMP-2 using ELISA. The researchers reported that MMP-2 levels in both serum and peritoneal fluid were higher in the endometriosis group, with a significant difference between serum and peritoneal fluid levels and a significant association between MMP-2 values and endometriosis. The paper also states that higher MMP-2 levels corresponded to higher endometriosis stage. This paper is centrally about endometriosis — it focuses on whether MMP-2 concentrations in serum and peritoneal fluid distinguish endometriotic patients and relate to disease stage.

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Abstract

Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher the value of MMP-2 serum andperitoneal fluid, the higher the stage of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 104-109]Keywords: endometriosis, matrix metalloproteinase-2, MMP-2

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endometriosis

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