UP-REGULATION OF MATRIX METALOPROTEINASES AND THEIR LATENT ROLE TO DEVELOP ENDOMETRIOSIS IN YOUNG FEMALES OF REGRESSIVE MENESTRUATION

Khokhar Mas; Muhammad Zeeshan Anwar; Arif Malik; M Bakowiec; R Maksym; P Wodarski; H Zhou; W Nothnick; H Birkedal-Hansen; W Moore; M Bodden; L Windsor; Birkedal Hansen; B; De Carlo; A; I Kokorine; M Nisolle; J Donnez; Y Eeckhout; P Courtoy; E Marbaix; R Gaetje; G Kotzian; R Herrmann; A Baumann; Starzinski-Powitz; N Baharuddin; N Abdullah; T Tessy; T St Maisuri; C Liu; Y Li; S Hu; Y Chen; L Gao; D Liu; Y Yang; E Samani; R Mamillapalli; F Li; L Mutlu; D Hufnagel; G Krikun; H Taylor; S Jana; A Ray; K Chatterjee; P Dasmahapatra; S Swarnakar; K Bruner-Tran; Z Zhang; E Eisenberg; R Winneker; K Osteen; M Hafeez; T Yasin; U Safdar; S Waquar; Rana Malik; R Khalil; Q Ali; A Malik; B Hameed; J Ali; A Siddique; A Fateh; N Idrees; M Rashid; M Kari; R Rashid; M Rana; A Amjad; M Omer; S Malik; M Anjum; A Riaz; R Ali; M Nadeem; Hafeez; Mm; A Khalid; U Daraaz; K Hussain; H Chudhary; A Amin; M Malik; S Ali; S Gillani; M Afzal; K Parveen

doi:10.31032/ijbpas/2021/10.2.5390c

UP-REGULATION OF MATRIX METALOPROTEINASES AND THEIR LATENT ROLE TO DEVELOP ENDOMETRIOSIS IN YOUNG FEMALES OF REGRESSIVE MENESTRUATION

Khokhar Mas, Muhammad Zeeshan Anwar, Arif Malik, M Bakowiec, R Maksym, P Wodarski, H Zhou, W Nothnick, H Birkedal-Hansen, W Moore, M Bodden, L Windsor, Birkedal Hansen, B, De Carlo, A, I Kokorine, M Nisolle, J Donnez, Y Eeckhout, P Courtoy, E Marbaix, R Gaetje, G Kotzian, R Herrmann, A Baumann, Starzinski-Powitz, N Baharuddin, N Abdullah, T Tessy, T St Maisuri, C Liu, Y Li, S Hu, Y Chen, L Gao, D Liu, Y Yang, E Samani, R Mamillapalli, F Li, L Mutlu, D Hufnagel, G Krikun, H Taylor, S Jana, A Ray, K Chatterjee, P Dasmahapatra, S Swarnakar, K Bruner-Tran, Z Zhang, E Eisenberg, R Winneker, K Osteen, M Hafeez, T Yasin, U Safdar, S Waquar, Rana Malik, R Khalil, Q Ali, A Malik, B Hameed, J Ali, A Siddique, A Fateh, N Idrees, M Rashid, M Kari, R Rashid, M Rana, A Amjad, M Omer, S Malik, M Anjum, A Riaz, R Ali, M Nadeem, Hafeez, Mm, A Khalid, U Daraaz, K Hussain, H Chudhary, A Amin, M Malik, S Ali, S Gillani, M Afzal, K Parveen

In: International Journal of Biology, Pharmacy and Allied Sciences · 2021 · vol. 10(2) · doi:10.31032/ijbpas/2021/10.2.5390c · W4205949407

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated matrix metalloproteinases (MMPs) MMP-2, MMP-7, and MMP-9 in glandular epithelial cells of endometriotic and normal endometrium to understand their role in endometriosis pathogenesis.

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Abstract

Endometriosis is defined as the presence of endometrium outside of uterine cavity and thought to develop through reverse menstruation of endometrial tissue into the peritoneal cavity. Endometrial cell implantation into peritoneal cavity is a crucial process in the onset of endometriosis. Interestingly during implantation some features of malignancy are demonstrated by endometrial cells, as they have the ability to attach and to invade the peritoneum or ovary structure. This invasion is effectuated with a group of enzymes known as matrix metalloproteinases (MMPs) which may contribute in extracellular matrix (ECM) degradation. ECMs and protein degrading activity of cell surface proteins play a critical role in pathophysiology of endometriosis. During inflammation activated neutrophils, macrophages and eosinophils stimulate the production of MMPs in peritoneal cavity of female with endometriosis. The objective of present study was to access the expression of MMP-2, MMP-7 and MMP-9 in glandular epithelial cells of endometriotic tissue and normal endometrium to elucidate the role of MMPs in the pathogenesis of endometriosis.

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endometriosis

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Cites (4)

References (17)

Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions via openalex
Micrometastasis of endometriosis to distant organs in a murine model via openalex
The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis via openalex
The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients via openalex
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[1] Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions 1997

[2] The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis 2005

[3] Micrometastasis of endometriosis to distant organs in a murine model 2017

[4] The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients 2018