Endometriosis Management: Workflow on Genomics and Proteomics and Future Biomolecular Pharmacotherapy

Keywords: Endometriosis, genomics, proteomics, GnRH agonists, angiogenesis, aromatase inhibitors, immune system, nonhormonal treatments, genetical predisposition Current Medicinal Chemistry Title: Endometriosis Management: Workflow on Genomics and Proteomics and Future Biomolecular Pharmacotherapy Volume: 15 Issue: 21 Author(s): Andrea Tinelli, Roberta Martignago, Daniele Vergara, Giuseppe Leo, Antonio Malvasi and Raffaele Tinelli Affiliation:

Endometriosis, genomics, proteomics, GnRH agonists, angiogenesis, aromatase inhibitors, immune system, nonhormonal treatments, genetical predisposition

Background: Endometriosis is an estrogen-dependent disease, associated with pelvic pain and infertility, with still limited knowledge of the pathogenesis, pathophysiology of related infertility and evolution. Objective: To investigate proteogenomic approaches and new trends of endometriosis treatment. Methods: A literature search was carried out for all articles on endometriosis related to immune system, and to nonhormonal, antiangiogenic and experimental therapies. Results/Conclusions: Classic endometriosis pharmacotherapy is represented by GnRH agonists, oral contraceptives and Type II progesterone receptor ligands. New proteomic and genomic technologies could help to clarify the aetiology of endometriosis and promise the rapid identification of a new generation of drugs with a specific molecular target, with the aim to ameliorate the patients quality of life. Export Options About this article Cite this article as: Tinelli Andrea, Martignago Roberta, Vergara Daniele, Leo Giuseppe, Malvasi Antonio and Tinelli Raffaele, Endometriosis Management: Workflow on Genomics and Proteomics and Future Biomolecular Pharmacotherapy, Current Medicinal Chemistry 2008; 15 (21) . https://dx.doi.org/10.2174/092986708785747571 | DOI https://dx.doi.org/10.2174/092986708785747571 | Print ISSN 0929-8673 | | Publisher Name Bentham Science Publishers | Online ISSN 1875-533X | Call for Papers in Thematic Issues Advance in Novel Drug and combined Therapies for Chronic Diseases Chronic diseases such as malignant tumors and rheumatoid arthritis have long plagued a large number of patients. Currently, the management of chronic diseases has entered a new stage of targeted regulation, precise intervention and integrated treatment. 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