Pelvic pain in endometriosis: is success of therapy gone in cigarette smoke?

Ágnes Koppán, J Hámori, I Vránics, János Garai, I Kriszbacher, József Bódis, Frank Oehmke, Hans-Rudolph Tinneberg, Miklós Koppán
In: Health · 2011 · vol. 03(09) , pp. 571–576 · doi:10.4236/health.2011.39098 · W2053111637
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that smokers undergoing endometriosis treatment reported less pain relief and poorer quality of life improvement compared to non-smokers.

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Abstract

The objective of the study was to assess potential individual factors influencing the efficacy of combined surgical and medical therapy in en-dometriosis patients with pelvic pain. For this purpose we performed a prospective study using a specifically designed questionnaire among patients suffering from persistent pelvic pain and undergoing laparoscopy and further GnRH analogue therapy in a university-based gyne-cologic department. Eighty-one women of re-productive age with histologically confirmed endometriosis were enrolled. A questionnaire gathered information from women on the fol-lowing groups of variables: age, marital status, education, reproductive and medical history including previous pregnancies and parity, knowledge of accompaniing pelvic disorders, concurrent cigarette smoking, as well as general quality of life estimates including self-image. Pelvic pain was scored using a visual analogue scale. Patients filled out the questionnaires before surgery and upon completing medical therapy. Data were statistically evaluated. After cessation of therapy, 53% of patients reported absence of pain. Only 12% of pain-free patients were smokers. This corresponded to slightly more than one third (35%) of all smokers in the study. However, 56% of non-smoker participants reported a positive outcome that proved to be significantly larger than the ratio of pain-free smoker participants (p = 0.02). Improvement in quality of life was reported by 74% of all patients, and only 9% of them were smokers. However, 47% were smokers among patients reporting no change or worsening in quality of life (p < 0.01). Based on our results, we can conclude, that regular smoking might have a disadvantageous impact on the success rate of combined surgical and medical therapy for endometriosis related pelvic pain.

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endometriosis

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