{"paper_id":"f6a5c42b-fbb9-4409-ac96-789fbb73f122","body_text":"Abstract\nKeywords: Endometriosis, genomics, proteomics, GnRH agonists, angiogenesis, aromatase inhibitors, immune system, nonhormonal treatments, genetical predisposition\nCurrent Medicinal Chemistry\nTitle: Endometriosis Management: Workflow on Genomics and Proteomics and Future Biomolecular Pharmacotherapy\nVolume: 15 Issue: 21\nAuthor(s): Andrea Tinelli, Roberta Martignago, Daniele Vergara, Giuseppe Leo, Antonio Malvasi and Raffaele Tinelli\nAffiliation:\nKeywords: Endometriosis, genomics, proteomics, GnRH agonists, angiogenesis, aromatase inhibitors, immune system, nonhormonal treatments, genetical predisposition\nAbstract: Background: Endometriosis is an estrogen-dependent disease, associated with pelvic pain and infertility, with still limited knowledge of the pathogenesis, pathophysiology of related infertility and evolution. Objective: To investigate proteogenomic approaches and new trends of endometriosis treatment. Methods: A literature search was carried out for all articles on endometriosis related to immune system, and to nonhormonal, antiangiogenic and experimental therapies. Results/Conclusions: Classic endometriosis pharmacotherapy is represented by GnRH agonists, oral contraceptives and Type II progesterone receptor ligands. New proteomic and genomic technologies could help to clarify the aetiology of endometriosis and promise the rapid identification of a new generation of drugs with a specific molecular target, with the aim to ameliorate the patients quality of life.\nExport Options\nAbout this article\nCite this article as:\nTinelli Andrea, Martignago Roberta, Vergara Daniele, Leo Giuseppe, Malvasi Antonio and Tinelli Raffaele, Endometriosis Management: Workflow on Genomics and Proteomics and Future Biomolecular Pharmacotherapy, Current Medicinal Chemistry 2008; 15 (21) . https://dx.doi.org/10.2174/092986708785747571\n| DOI https://dx.doi.org/10.2174/092986708785747571 |\nPrint ISSN 0929-8673 |\n| Publisher Name Bentham Science Publishers |\nOnline ISSN 1875-533X |\nCall for Papers in Thematic Issues\nAdvance in Novel Drug and combined Therapies for Chronic Diseases\nChronic diseases such as malignant tumors and rheumatoid arthritis have long plagued a large number of patients. 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Artificial intelligence (AI) and machine learning are fundamentally reshaping the drug discovery and ...read more\n- Author Guidelines\n- Bentham Author Support Services (BASS)\n- Graphical Abstracts\n- Fabricating and Stating False Information\n- Research Misconduct\n- Post Publication Discussions and Corrections\n- Publishing Ethics and Rectitude\n- Increase Visibility of Your Article\n- Archiving Policies\n- Peer Review Workflow\n- Order Your Article Before Print\n- Promote Your Article\n- Manuscript Transfer Facility\n- Editorial Policies\n- Allegations from Whistleblowers\n- Announcements\nRelated Articles\nCurrent Genomics Furocoumarins from Cnidium monnieri Act as Peroxisome Proliferatoractivated R and Farnesoid X Receptor Agonists\nMini-Reviews in Organic Chemistry Current Indications for Implantable Cardioverter Defibrillators in Non-Ischemic Cardiomyopathies and Channelopathies\nReviews on Recent Clinical Trials DephosSitePred: A High Accuracy Predictor for Protein Dephosphorylation Sites\nCombinatorial Chemistry & High Throughput Screening Key miRNAs in Modulating Aging and Longevity: A Focus on Signaling Pathways and Cellular Targets\nCurrent Molecular Pharmacology Treatment of Choroidal Neovascularization in High Myopia\nCurrent Drug Targets Diabetic CVD – Focus on Vitamin D\nCardiovascular & Hematological Agents in Medicinal Chemistry Functional Null Mutations in the Gonosomal Homologue Gene TBL1Y are Associated with Non-Syndromic Coarctation of the Aorta\nCurrent Molecular Medicine Monoclonal Antibodies in Allergy; Updated Applications and Promising Trials\nRecent Patents on Inflammation & Allergy Drug Discovery The HGF-Met Signaling Axis: Emerging Themes and Targets of Inhibition\nCurrent Protein & Peptide Science Biosafety Considerations Using Gamma-Retroviral Vectors in Gene Therapy\nCurrent Gene Therapy Kynurenine Pathway and Disease: An Overview\nCNS & Neurological Disorders - Drug Targets PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile\nCurrent Pharmaceutical Design Natural Substances in the Fight of SARS-CoV-2: A Critical Evaluation Resulting from the Cross-Fertilization of Molecular Modeling Data with the Pharmacological Aspects\nCurrent Medicinal Chemistry The Impact of Crystallographic Data for the Development of Machine Learning Models to Predict Protein-Ligand Binding Affinity\nCurrent Medicinal Chemistry Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials\nCurrent Cancer Drug Targets Effect of Doxycycline on Atherosclerosis: From Bench to Bedside\nRecent Patents on Cardiovascular Drug Discovery Vascular Calcification in Chronic Kidney Disease: Role of Disordered Mineral Metabolism\nCurrent Pharmaceutical Design Effects of Opiates and HIV Proteins on Neurons: The Role of Ferritin Heavy Chain and a Potential for Synergism\nCurrent HIV Research Therapeutic Neovascularization by the Implantation of Autologous Mononuclear Cells in Patients with Connective Tissue Diseases\nCurrent Pharmaceutical Design","source_license":"CC0","license_restricted":false}